Climate change is a global event that poses one of humanity's most serious threats. Consequently, climate-smart agriculture (CSA) provides a once-in-a-lifetime opportunity to adapt to the effects of global climate change while lowering greenhouse gas emissions. The purpose of this study was to investigate the factors that influence farmers' adoption of CSA practices in the Wondo Genet Woreda in southern Ethiopia. The study employed a mixed-methods approach with 213 randomly selected households (HHs). In the study, descriptive statistics, a composite score index, and an ordered logit regression model were used. Farmers' awareness of CSA practices was high, which aided them in increasing farm income and farmland productivity. Tree planting, the use of organic manure, and the use of irrigation systems were the most CSA practices in the study area. Furthermore, the findings revealed that education, HH size, income, climate change perception, and farmland size all had statistically significant effects on farmers' adoption of CSA. Meanwhile, the distance between the farm and the homestead had a negative and significant effect on the level of CSA adoption. Finally, socioeconomic factors should be considered when developing and implementing CSA programs for farmers.