Background: Prostate is fibromusculoglandular organ encircling the neck of the urinary bladder, Benign prostate hyperplasia, prostate carcinoma and prostatitis are three pathologic processes which frequently affect the prostate gland.Prostatic enlargement causes urinary symptoms of static (hesitancy,retention) and dynamic (urgency,dribbling) nature.PSA is a glycoprotein which is expressed by both normal and neoplastic prostate tissue.PSA is used widely as a screening tool for carcinoma prostate.Gleason's microscopic grading is a paramount feature and with PSA are important for diagnosis,management,and prognosis of carcinoma.The purpose of this study is to frame evidence based PSA levels for various prostatic lesions.Method:This prospective study was done on total 50 samples.The samples taken were both transurethral resection of prostate and prostatic biopsies.All were grossed,sectioned,stained using H & E,viewed under microscope and graded by Gleason's scoring. Result:Total 50 samples were studied,out of which 46 were benign and 4 malignant.Mean age of the cases was 63.13 years.8% patients had PSA values more than 20 ng/ml. Conclusion: PSA is specific for prostate and is one of the best screening tools available for early detection of prostate cancer as it is a well accepted, simple, safe and cost effective method. The early diagnosis of clinically significant cancer obtained by evaluation of PSA levels helps in immediate and effective treatment.

Novel corona virus epidemic started in Dec 19 in Wuhan,China and soon it spread globally and became an international emergency Our objective was to study the role of hematological and biochemistry markers in assessing the disease severity and prognosis of laboratory confirmed,hospitalized Covid 19 patients.130 patients were included in this crosssectional retrospective study and divided into mild/moderate and severe/critical group.Correlation analysis was done for laboratory biomarkers.We found that mean age,lactate dehydrogenase (LDH),S.ferritin,urea,uric acid,D-dimer and S.creatinine of severely ill patients were significantly higher than those of patients with non-severe illness. Leucopenia and neutropenia were also associated with disease severity.Males were affected more than females with both mild and severe illness. Following parameters like S. Ferritin, LDH,TLC, neutrophil % can help in identifying the progression of disease from mild to severe and help in adopting appropriate measures in the management so that progression can possibly be prevented. Rising levels of some parameters like D.dimer, urea, uric acid and creatinine also help in explaining the prognosis of patient.