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Optoelectronic semiconducting polymer material interfaced with a blind-developing chick-retina (E13-E18) in subretinal configuration reveals a response to full-field flash stimulus that resembles an elicited response from natural photoreceptors in a mature chick retina. The response manifests as evoked-firing of action potentials was recorded using a multi-electrode array in contact with the retinal ganglion layer. Characteristics of increasing features in the signal unfold during different retina-development stages and highlight the emerging network mediated pathways typically present in the vision process of the artificial photoreceptor interfaced retina.

We perform microelectrode array recordings of neonatal chick retina explants and report stimulus-dependent response properties of different retinal ganglion cell types to various luminance and contrast adaptation conditions. The isolated single units indicate wavelength-sensitive response properties of most of the putative retinal ganglion cells recorded. Responses to different luminance and contrast conditions were investigated as a function of wavelength indicating a combination of adaptation and sensitization features. We also demonstrate the presence of color opponency between blue (450 nm) and green (530 nm) light input. The analysis of their STA profiles to the full field random gaussian flicker stimulus reveals a green ON/blue OFF RGC type and a blue ON/green OFF RGC type.

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