Due to the oral route’s comfort, convenience, and patient compliance, it is the most important and advised method for administering medications. The typical oral unit dosage form that is most frequently employed is the tablet. The patients experience problems swallowing during pill administration. Tablets called mouth dissolving tablets (MDTs) that quickly dissolve in the mouth without the need of water can lessen this issue. As a new drug delivery system, MDTs have begun to acquire recognition and appeal. By developing a simple-to-use dosage form that will increase compliance, they hope to increase the safety and efficiency of therapeutic molecules. For individuals with dysphasia, such as children, the elderly, and those who are mentally ill, mouth dispersing medications are becoming more reliable. The introduction, benefits, drawbacks, excipients employed, different formulation procedures, and evaluation factors are all covered in this review.