Esophageal squamous cell carcinoma is one of the common types of malignant lesion and has its highest prevalence round the world.  Though it is a common disorder, many of the patients only diagnose it in its advanced stage and these results in poor prognosis of the disease. In later stage, these lesions may severely develop in to lymph node metastasis and has more chances to spread across any of the vital organs. Barrett‟s esophagus, herpes simplex esophagitis, candidial esophagitis, leiomyoma, hyperplastic polyps are few of the benign and premalignant type of lesions.  The advancement in endoscopy has opened many opportunities and diagnosis of all esophageal lesions became simple and effective. As the surgical procedures associated with the targeted therapy have become promising option for the treatment, many patients are being benefited out of technological advancement. The surplus of malignancies such as esophagus, esophago- gastric junction and stomach have become a significant health problem and threatening the people all over the world. Delayed diagnosis on these disorders particularly resulting in high mortality ratio and warrant for a systematic evaluation in patients.  In this context, the present study analyse the association and prognostic significance  of HER2/ neu in gastroesophageal lesions with other factors like age, size, histological type and grading and  the incidence and distribution of gastroesophageal lesions in patients.