Introduction: Typhoid fever is preventable infectious diseases caused by gram negative bacteria Salmonella typhi and is still a major public health problem in India. Objective: The main aim of our study was to find out the clinical profile in admitted pediatric patients of typhoid fever. Design: Retrospective case study .Subjects: 292 hospitalized Widal positive typhoid fever pediatric cases admitted to tertiary care hospital from1 st August 2014 to 31 st July 2015. Methods: Records of all the patients who were discharged with the diagnosis of Widal Positive enteric fever were retrieved, compiled and analyzed. Results: Out of 292 total patients: 18(6.16 %) were below 2 years of age; 54(18.49%) cases were between 2-5 years; 124(42.46%) were between 5 to 10 years of age and 96 (32.87%) were above 10 years of age. Fever was the main presenting complains in all cases. Vomiting (49.31%), diarrhea (36.98%) and cough (33.56) were common associated complains. Almost all (289, 98.97%) patients were treated with Injection ceftriaxone after positive Widal reports to start with. Only in 62(21.23%) patients, oral Azithromycin was added along with ceftriaxone. 58.20% patients required more than 6 days hospital stay. Conclusion: The incidence of typhoid fever was 5.63 % amongst the total admitted patients. Typhoid fever is having high morbidity but with availability of third generation cephalosporin, mortality has reduced. 24.65% patients were below 5 years of age which shows changing trends in age of presentation which was considered rare below 5 years of age.

AIM:To find out etiology, clinical profile and complications of fever with thrombocytopenia. TYPE OF STUDY: Observational study. MATERIAL AND METHOD: The study was conducted at Tertiary Hospital in Ahmadabad in month of December, 2014. Patients up to 14 year of age admitted in pediatric ward with fever with thrombocytopenia were included in study. Patients were managed according to institute protocol for individual condition and associated complication they had. Performa were filled and analysis was done. RESULTS: Total 447 patients admitted in pediatric ward during study period 86 (19.23%) patients included in study. Severe thrombocytopenia seen in 36 (41.86%), moderate in 26 (30.23%) and mild in 24 (27.90%) patients. Most common cause for thrombocytopenia was dengue fever 40 (46.51%) patients and second most common was viral fever other than dengue fever 17 (19.76%) patients. Other causes were malaria 10 (11.62%), enteric fever 5 (5.81%), megaloblastic anemia 2, viral hepatitis 2. Commonest age group involved was 6-10 year (39.53%) with average duration of hospital stay 4-7 days (72 %). Blood product transfusion required in 10 (11.62%) patient of them only 3 (3.48%) require PRC transfusion [one for dengue fever with hemetemesis, second for complicated p.falciparam malaria and for septicemia with DIC]. Out of 10 total malaria patients 5 shows severe thrombocytopenia and 3 of them require PCV transfusion. 2 patient expired included in study one 6 month female had DIC with acute respiratory failure with septicemia other was 10 month male had septic shock with megaloblastic anemia. CONCLUSION: Viral infection was the most common cause of fever with thrombocytopenia, only supportive care was required and platelet count became normal without any complication in short period. PRC transfusion was least likely required even in severe thrombocytopenia.

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