The rapid development of vaccines to combat COVID-19 is a great scientific achievement. In addition to non-pharmaceutical measures put in place to contain of the pandemic, pharmacological measures have been incorporated in the battle against the SARS-CoV-2, especially with the commencement of vaccination in early December 2020. This study used the SIDARTHE-V model, i.e.an extension of the SIDARTHE model with the impact of vaccination roll outs.We assessed the potential impact of vaccination in reducing the severity (deadly nature) of the virus in African countries. Model parameters were extracted by fitting simultaneously the COVID-19 cumulative data of active cases, recoveries, deaths and full vaccinations reported by the governments of Ghana, Kenya,