In this randomized trial, 121 mandated college students (33% female, 74% Caucasian, M age ϭ 19.42 years) received either a Brief Motivational Intervention (BMI) with personalized normative feedback (PNF) or the Expectancy Challenge Alcohol Literacy Curriculum (ECALC) to compare effectiveness in reducing alcohol use and associated harms. All participants received either BMI content (n ϭ 63) or ECALC (n ϭ 58). ECALC was delivered as a web-based program with clinician assistance. Measures of alcohol use and harms were completed at baseline and 4 weeks postintervention. ECALC produced significant reductions on all 4 positive expectancy subscales of the Comprehensive Effects of Alcohol Scale (CEOA). Both programs were associated with significant reductions on all alcohol use variables and harms, and expectancies significantly mediated the intervention to outcome relationship in the ECALC condition. There were no significant gender differences. Two one-sided equivalence test indicated superior effects for ECALC compared to BMI on four alcohol use variables (mean blood alcohol concentration, peak blood alcohol concentration, peak drinks per sitting, and drinking days per month), and noninferior to BMI in reducing others (mean drinks per sitting, mean drinks per week, & binge drinking). Superior effects of ECALC versus BMI are based on a short-term follow-up, and longevity of ECALC effects have yet to be established. ECALC has previously been found to be effective as a group-delivered program for male fraternity members, and these findings provide preliminary support for effectiveness for both males and females when delivered individually using a web-based clinician-assisted format.