HER2 is a known therapeutic target for about 30% of breast cancer patients where HER2 is over expressed and this is referred to as
HER2 positive breast cancer. This subtype is characterized by a clinical behavior know to be especially aggressive. Improved HER2
targeting agents such as trastuzumab, pertuzumb, lapatinib and ado-trastuzumab emtansine are available. Some patients have shown
no response to treatment while others show progress to these agents. Therefore, it is of interest to screen HER2+ with phyto-chemical
lead compound from Ginkgo biloba using molecular docking techniques. We screened 25 phyto-chemicals from literature with HER2+.
Results show that cianidanol have an acceptable binding energy of (-8.2kcal/mol). Thus, we report the binding properties of cianidanol
with HER2+.
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