We report 13 cases of pulmonary pneumocystis (PCP) in human immunodeficiency virus (HIV)-uninfected patients. Of eight males and five females, with a mean age of 55 years, one had breast neoplasia, two had common variable immunodeficiency (CVID), one had an autoimmune disease "Goodpasture's syndrome", and one had idiopathic fibrosis (nonspecific interstitial pneumonia/fibrosis (NIP)) undergoing prolonged corticosteroid therapy for two years, with no known immunosuppression in the remaining cases. The clinical picture was characterized by constant dyspnea and severe hypoxia in 11 cases. Lymphopenia was present in nine cases with an average rate of 920.76 elements/mm 3 . The diagnosis was confirmed by isolation of Pneumocystis jirovecii (PCJ) from induced sputum, except in two cases where analysis of bronchoalveolar lavage (BAL) fluid was required. With trimethoprim/sulfamethoxazole (TMP/SMX) and corticosteroid therapy, the course was favorable in all cases. Prophylactic treatment was indicated in three cases.

Introduction:Sarcoidosis is a non-necrotizing systemic granulomatosis of unknown cause characterized by a predominant pulmonary tropism. It is a disease of very variable manifestation and evolution. Its evolutionary course is difficult to predict: from spontaneous resolution in the absence of treatment to progressive organ destruction despite several lines of therapy. Objectives: The aim of our study is to describe the evolutionary profile of mediastinopulmonary sarcoidosis followed in the pneumology department of CHU Hassan II Fez. Material and methods:This is a retrospective study, covering the cases of mediastinopulmonary sarcoidosis followed in our department between January 2016 and December 2019 we required a follow-up period of at least 3 years to be able to retain the cure. Results:We collected 41 patients, the average age was 45.68 years (28-65), with a clear female predominance, 95 ,1% of women, type I was found in 12.2% of cases, type II in 73.2% of cases, type III in 7.3% of cases, and type IV in 7.3% of cases also. Histological confirmation was obtained by mediastinoscopy in 41.5% of cases, and by staged bronchial biopsies in 46.4% of cases. We opted for a therapeutic abstention in 46.3% of the cases (19 patients), 3 of them required treatment during their follow-ups. 22 patients required treatment with oral corticosteroids from the start, 4 relapses were noted after stopping corticosteroids, 4 patients required a second line of azathioprine, and 15 patients were cured after at least 3 years of no treatment.