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Virtual poster abstractsMethods: This was a prospective cohort observational study that included 228 fetuses, of which there were 15 cases of hypoplastic left heart syndrome (HLHS), 21 cases of an atrioventricular septal defect (AVSD), 15 cases of a double inlet ventricle, 14 cases of tricuspid atresia, 11 cases of tricuspid valve dysplasia, including Ebstein anomaly, 24 cases of d-transposition of the great arteries (TGA), 15 cases of tetralogy of Fallot, 12 cases of double outlet right ventricle (DORV), 25 cases of pulmonary stenosis or atresia, 6 cases of aortic valve stenosis (AS), 43 cases of coarctation of the aorta (CoA) or interrupted aortic arch, 25 cases of isolated right aortic arch, and 2 cases of isolated anomalous pulmonary venous connection (APVC). Results: Developmental abnormalities of the CC were revealed in 15 (6.6%) fetuses, which included 1 case of complete and 2 cases of partial agenesis of the CC, 10 cases of dysgenesis or hypoplasia of the CC, 1 case of a combination of hypoplasia of the CC and cerebellar vermis, and 1 case of a combination of sulcation anomaly with hypoplasia of the CC. The frequency of callosal anomalies, depending on the type of CHD, was 26.7% (4/15) in cases of tetralogy of Fallot; 6.6% (1/15) in cases of HLHS, 16.7% (2/12) in cases of DORV; 4.6% (2/ 43) in cases of obstructive aortic arch lesions; 8% (2/25) in cases with right aortic arch; 7.1% (1/14) of cases with tricuspid atresia; 4.8% (1/21) in cases of AVSD; 4% (1/25) in cases of pulmonary stenosis or atresia. In one of two fetuses with isolated APVC, hypoplastic corpus callosum was also revealed. Conclusions: Based on these preliminary data, we can conclude that fetuses with congenital heart defects are at high risk for callosal abnormalities, and further research in needed to obtain more clinical data and subsequent interpretation of postnatal results.

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