BACKGROUND The technique of "coinduction", i.e. use of a small dose of sedative agent or another anaesthetic agent reduces the dose requirement as well as adverse effects of the main inducing agent. Ketamine, midazolam and propofol have been used as coinduction agents with propofol. MATERIALS AND METHODS This prospective, randomised clinical study compared to three methods of coinduction. One group received ketamine, one group received midazolam and one group received propofol as coinducing agent with propofol. RESULTS The study showed that the group receiving ketamine as coinduction agent required least amount of propofol for induction and was also associated with lesser side effects. CONCLUSION Use of ketamine as coinduction agent leads to maximum reduction of induction dose of propofol and also lesser side effects as compared to propofol and midazolam.