A prognostic approach based on a MISO (multiple inputs and single output) fuzzy logic model was introduced to estimate the pressure difference across a gas turbine (GT) filter house in a heavy-duty power generation system. For modelling and simulation of clogging of the GT filter house, nine real-time process variables (ambient temperature, humidity, ambient pressure, GT produced load, inlet guide vane position, airflow rate, wind speed, wind direction and PM10 dust concentration) were fuzzified using a graphical user interface within the framework of an artificial intelligence-based methodology. The results revealed that the proposed fuzzy logic model produced very small deviations and showed a superior predictive performance than the conventional multiple regression methodology, with a very high determination coefficient of 0.974. A complicated dynamic process, such as clogging phenomenonin heavy-duty GT system, was successfully modelled due to high capability of the fuzzy logic-based prognostic approach in capturing the nonlinear interactions.