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Background: The MIND diet has been linked with prevention of cognitive decline but has not been fully assessed in the context of Parkinson's disease (PD). Objective: To determine whether MIND diet adherence is associated with the age of Parkinson's disease onset. Methods: Food Frequency Questionnaires from 181 participants with PD were scored for MIND adherence and correlated with age of onset using univariate and multivariate linear models. Results: MIND adherence scores positively correlated with age of onset both independently (p=9.7e-5) and in models including education, sex, disease duration, caloric intake, smoking, and exercise. Differences in age of PD onset in the high vs the low adhering tertiles corresponded to 6 years for men and 10.2 years for women. Effect sizes exceeded those previously reported for the Mediterranean diet. Conclusions: These preliminary data suggest that the MIND diet may be an effective PD-delaying intervention, especially in women.

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