Signal transduction through the Mitogen Activated Protein Kinase (MAPK) pathways is evolutionarily highly conserved. Many cells use these pathways to interpret changes to their environment and respond accordingly. The pathways are central to triggering diverse cellular responses such as survival, apoptosis, differentiation and proliferation. Though the interactions between the different MAPK pathways are complex, nevertheless, they maintain a high level of fidelity and specificity to the original signal. There are numerous theories explaining how fidelity and specificity arise within this complex context; spatio-temporal regulation of the pathways and feedback loops are thought to be very important. This paper presents an agent based computational model addressing multi-compartmentalisation and how this influences the dynamics of MAPK cascade activation. The model suggests that multi-compartmentalisation coupled with periodic MAPK kinase (MAPKK) activation may be critical factors for the emergence of oscillation and ultrasensitivity in the system. Finally, the model also establishes a link between the spatial arrangements of the cascade components and temporal activation mechanisms, and how both contribute to fidelity and specificity of MAPK mediated signalling.

Gas turbine engines are complex machines that typically generate a vast amount of data, and require careful monitoring to allow for cost-effective preventative maintenance. In aerospace applications, returning all measured data to ground is prohibitively expensive, often causing useful, high value, data to be discarded. The ability to detect, prioritise, and return useful data in real-time is therefore vital. This paper proposes that system output measurements, described by a convolutional neural network model of normality, are prioritised in real-time for the attention of preventative maintenance decision makers.Due to the complexity of gas turbine engine timevarying behaviours, deriving accurate physical models is difficult, and often leads to models with low prediction accuracy and incompatibility with real-time execution. Data-driven modelling is a desirable alternative producing high accuracy, asset specific models without the need for derivation from first principles.We present a data-driven system for online detection and prioritisation of anomalous data. Biased data assessment deriving from novel operating conditions is avoided by uncertainty management integrated into the deep neural predictive model. Testing is performed on real and synthetic data, showing sensitivity to both real and synthetic faults. The system is capable of running in real-time on low-power embedded hardware and is currently in deployment on the Rolls-Royce Pearl 15 engine flight trials.

Machine learning classifiers using surface electromyography are important for human-machine interfacing and device control. Conventional classifiers such as support vector machines (SVMs) use manually extracted features based on e.g. wavelets. These features tend to be fixed and non-person specific, which is a key limitation due to high person-to-person variability of myography signals. Deep neural networks, by contrast, can automatically extract person specific features -an important advantage. However, deep neural networks typically have the drawback of large numbers of parameters, requiring large training data sets and powerful hardware not suited to embedded systems. This paper solves these problems by introducing a compact deep neural network architecture that is much smaller than existing counterparts. The performance of the compact deep net is benchmarked against an SVM and compared to other contemporary architectures across 10 human subjects, comparing Myo and Delsys Trigno electrode sets. The accuracy of the compact deep net was found to be 84.2 ± 6% versus 70.5 ± 7% for the SVM on the Myo, and 80.3 ± 7% versus 67.8 ± 9% for the Delsys system, demonstrating the superior effectiveness of the proposed compact network, which had just 5,889 parameters -orders of magnitude less than some contemporary alternatives in this domain while maintaining better performance.

Movement classification from electromyography (EMG) signals is a promising vector for improvement of human computer interaction and prosthetic control. Conventional work in this area typically makes use of expert knowledge to select a set of movements a priori and then design classifiers based around these movements. The disadvantage of this approach is that different individuals might have different sets of movements that would lead to high classification accuracy. The novel approach we take here is to instead use a data-driven diagnostic test to select a set of person-specific movements. This new approach leads to an optimised set of movements for a specific person with regards to classification performance.