Objective-To examine the correlation between CT-based and radionuclide renogram-based measures of split renal function within a normal population of potential live kidney donors by use of 3D models generated from CT angiography.Materials and Methods-173 renal donor candidates were retrospectively evaluated with CT and radionuclide renogram between March 1, 2005 and February 28, 2006, of whom 152 met study inclusion criteria. A blinded investigator using 3-D models created semi-automatically from the precontrast, arterial and excretory phases made measurements of CT renal volumes and attenuations. Mean renal attenuation and volume were used to calculate the net accumulation of contrast, and split renal function for comparison with radionuclide renography. Split function from CT was calculated in the arterial and excretory phases as well as based on split renal volume and the Patlak method.Results-All four CT-based methods for the calculation of split renal function showed correlation with no significant difference from radionuclide renography (p>0.05, t test). Pearson correlations varied from 0.36 to 0.63 (p<0.001 for each). Difference scores revealed that the excretory and renal volume splits had the narrowest range, and demonstrate a linear, non-zero relationship to the renogram splits. Bland-Altman analysis confirms that the majority of difference scores between each CT method and the radionuclide renogram fall within the 95% CI of the differences.Conclusion-Split renal function based on 3D CT models can provide "one-stop" evaluation of both the anatomic and functional characteristics of the kidneys of potential live kidney donors. The excretory phase data and the split renal volume data show the best correlation and the smallest difference scores.

Results indicate promise for the Stamp-in-Safety program as a low-cost, easily implemented intervention to reduce pediatric playground injury risk at childcare centers. Suggestions for future research are offered.

In the anterior projection, pinhole collimation is superior to parallel-hole collimation for parathyroid imaging with either dual-phase (99m)Tc-sestamibi or dual-phase (99m)Tc-sestamibi plus dual-tracer ((99m)Tc-sestamibi and (123)I) simultaneous-acquisition subtraction.

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