This article provides an insight on detailed current advances in molecular understandings of periodontal ligament cells and the influence of orthodontic force on them in the light of recent advances in molecular and genetic sciences. It sequentially unfolds the cellular events beginning from the mechanical force initiated events of cellular responses to bone remodeling. It also highlights the risks and limitations of orthodontic treatment in certain periodontal conditions, the important areas of team work, orthodontic expectations from periodontal treatment and the possibility of much more future combined research to improve the best possible periodontal health and esthetic outcome of the patient.

The loss of lower molars often leads to over-eruption of the opposing maxillary molars, combined with insufficient clearance for lower prosthetic restorations. The available treatment options are either a significant reduction of the maxillary teeth, often associated with endodontic treatment, or removable appliances such as headgear which depend on patient compliance; a complex fixed orthodontic treatment, which may involve unwanted side-effects, or a segmental impaction involving all the risks of surgery and patient discomfort. In previous years, different cases of orthodontic intrusion with miniscrew implants have been described, which make use of four or more miniscrews for bilateral maxillary molar intrusion. In this report, a case is presented requiring bilateral maxillary molar intrusion in order to get sufficient space for an implant-supported fixed restoration in the lower posterior region. This intrusion was carried out simultaneously on both sides by means of three miniscrew implants and a customized transpalatal arch. The results showed significant intrusion of the supra-erupted maxillary molars with normal and acceptable biological response of the teeth and the surrounding bony structures. CPD/Clinical Relevance: This paper presents a case report demonstrating a new clinical technique to intrude supra-erupted maxillary molars simultaneously on both sides with the use of three miniscrew implants instead of the conventional four, and a customized transpalatal arch which is simple to fabricate. The technique shows effective results in terms of intrusion achieved and the absence of clinically detectable apical root resorption of the intruded molars.