Background:Indonesia reported ≥1 million cases of Coronavirus Disease (COVID-19) with remarkable number of deaths. Notably, hypertension's status as predictor for poorer outcome remains debatable.Objective:We aim to investigate the association between in-hospital mortality and hypertension in COVID-19 patients.Methods:A retrospective study using adult (≥18 years old), confirmed COVID-19 patients’ medical record at Cibabat General Hospital, Cimahi, West Java, Indonesia between September to December 2020 was conducted. Patient's gender, age, hospital-stay length, comorbidities (type 2 diabetes mellitus, coronary artery diseases, arrythmia, kidney diseases, respiratory diseases, and stroke), and outcomes were collected. Hypertension was defined as hypertension history before the infection. Chi-square and logistic regression analysis were conducted to understand the association between hypertension and mortality.Results:A total of 205 patients were included, 117 (57.1%) were males, of whom 40 (19.5%) died and 165 (80.5%) were discharged. The mean value of the patients’ age was 53.7 ± 13.8 years old, and the median hospitalization-day was 11 (range: 1–45) days. Hypertension was the most common comorbidity (n = 72; 35.1% patients); 13 (18.1%) were dead and 59 (81.9%) survived. A chi-square test showed no statistically significant difference between mortality and hypertension, X2 (1, N = 205) = 0.15, p = 0.70; OR: 0.87, 95% confidence interval (CI) 0.42–1.80. Logistic regression analysis reveals that patient's age is the only statistically significant factor for death in this study (p < 0.05; OR: 1.05, 95% CI 1.02–1.08).Conclusion:Hypertension is not associated with mortality in COVID-19 patients. Further investigations including larger sample size and more possible variables are warranted to understand this relationship further.

Background: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is marked as one of the highly pathogenic viruses, resulting in millions of deaths worldwide. Management of COVID-19 in limited resources requires appropriate decisions. Clinical considerations along with simple laboratory parameters that can predict the worsening are needed to determine which patients should be treated more intensively.  Methods: This is a retrospective cohort study based on the Research Electronic Data Capture (REDCap) registry of COVID-19 patients in Hasan Sadikin General Hospital from April to December 2020. Patients were divided into worsening and non-worsening groups within a 14-day follow-up. Factors affecting these conditions were analyzed. Results: A total of 537 patients were included in this study, of which 72 patients suffered deterioration. Multivariate analysis showed the significant factors affecting the worsening of COVID-19 patients were age > 60 years (aOR 4.207, 95% CI 2.13-8.32), heart disease (aOR 2.802, 95% CI 1.12-6.99), diabetes mellitus (aOR 3.107, 95% CI 1.43-6.74), respiratory rate > 23x/minute (aOR 3.71, 95% CI 1.87-7.38), and NLR > 3.8 (aOR 2.51, 95% CI 1.21-5.21). Conclusions: Older age, chronic heart disease, diabetes mellitus, tachypnea, and higher neutrophil-to-lymphocyte ratio (NLR) are risk factors for the clinical worsening of COVID-19 and can be useful to predict the worsening outcome and poor prognosis.