Construction sites have been identified as one of the most hazardous places to work due to high level of health and safety risks. Information on health and safety is therefore required to educate the participants on how to achieve safe working environment. This study therefore examined and analysed level of knowledge and compliance with information on health and safety and the effects on the safety of construction workers in Nigeria. Findings from the study revealed that the workers have average knowledge of health and safety information but demonstrated low level of compliance. The result also established a very strong positive correlation between compliance of health and safety information and safety of workers. However, when the significance of the correlation was tested, the result implied that though there was a positive relationship between compliance and safety of workers, the relationship was not significant. Practically, this meant that compliance alone cannot substantially guarantee workers safety.