Annona senegalensis is a traditional medicinal plant commonly used in traditional medicine for the treatment of various diseases. It belongs to a family of Annonaceae and commonly known by the name of Wild Custard Apple and Wild Soursop, etc. It is a shrub or small tree 2-6 m tall but may reach 11m under favorable conditions. It is widely spread throughout tropics and sub-tropics. It is commonly used for therapeutic fighting of major diseases including dysentery, diabetes mellitus, heart stroke, epilepsy, parasite and worm infestations, constipation, hemorrhage, dysuria, fever, ulcer, and cancers. The plant has also been reported for several biological activities including anti-oxidant, antidiarrheal, antimicrobial, antiparasitic, anticonvulsant, antitrypanosomal, antimalarial, anti-inflammatory, anti-snake venom, and antinociceptive properties. In order to provide sufficient baseline information for future works and commercial exploitation, this review represents the ethnomedicinal properties, phytochemicals composition, pharmacological properties, and safety/toxicity profile of A. senegalensis.