In the present study a series of unsymmetric linear sulfamides (1-9) starting from a primary amine were synthesized and their structures were confirmed by elemental analyses, mass spectrometry and 1 H NMR techniques. All the synthesized compounds were screened for their antibacterial activities by both disc diusion and minimal inhibition concentration (MIC) methods. Frontier molecular orbital (FMO) analysis and global reactivity descriptors have been performed using the density functional theory (DFT) with the B3LYP functional. The results indicated that these derivatives, depending of their substituted radical, bring about an improvement in the bacterial activity.

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Apitherapy is one of the practices in natural care, based on products of the hive such as: honey, royal jelly, propolis ... etc. Propolis is a resinous product gathered by honey bees from tree buds (Dimov et al., 1991;Amoros et al., 1992). Its main constituents are beeswax, resin and volatile matter. Mostly, the biological activity of propolis is ascribed to these plant-extracted substances. It has been appeared to have pharmacological properties for example antibacterial, antifungal, antiviral, anti-inflammatory, antioxidant and immunostimulant (Silici et al., 2007). Successful medical experiments with propolis have prompted expanded interest in its chemical composition and origin. For quality control purposes, chemical tests should be joined with biological tests, particularly antimicrobial tests. The antimicrobial activity of propolis has been broadly studied, affirming its antibacterial, antifungal, antiviral and antiprotozoal character (Vardar-Ünlü et al., 2008). Krol et al. (1993) detailed that propolis extracts potentiate certain antibiotic effects attributing the antimicrobial activity of propolis for the most part to flavonoids or to a synergy between certain phenolic components (Vijay, 2013). The main bioactive components coming from North American and European sources are flavanones, flavones and flavanols. Apart from flavonoids, aldehydes, alcohols, aromatic and aliphatic acids, amino acids, chalcones, steroids, sugars and terpenoids have additionally been detected in propolis (Silici et al., 2007). Numerous experiments have been carried out on the chemical constitution of propolis, the results of which have shown that this composition depends on the botanical source of this resin. Propolis of temperate areas is essentially composed of phenolics such as flavonoids and cinnamic acid byproducts. Besides these compounds, tropical propolis are rich in diterpenes, lignans and some other prenylated compounds (Segueni, 2011). Algeria, despite its geographical position which differs from the other areas mentioned above, is likely to supply different propolis, especially from a chemical viewpoint. The antimicrobial activity and chemical properties of propolis are essential parameters for its characterization (Silici et al., 2007). All these data led us to study the biological properties of two propolis from Eastern Algeria. A comparative study based on antimicrobial activity was carried out: the antibacterial and antifungal effects of propolis extracts were tested on clinically pathogenic microorganisms including bacteria, fungus and yeast. An analysis of the chemical composition of the propolis extracts in order to discover their main components. Our work focused on polyphenols and more particularly flavonoids, which are essential elements of several biological activities of propolis, like the antimicrobial one. The identification and structure determination of these components is carried out by visible UV spectrometry, as well as other chromatographic techniques. MATERIAL AND METHODS Material usedThe propoli...

A new actinomycete strain, designated AA13 was isolated from a marine sediment sample obtained from Lake Oubeira, in the NorthEast of Algeria and selected for its antifungal activities against Candida albicans. Morphological, physiological and biochemical properties and 16S rRNA gene sequencing strongly suggested that this strain was a new species, which belonged to the genus Streptomyces. Study of the influence of different nutritional compounds and culture conditions on growth and production of compounds with antifungal activity by the Streptomyces sp. strain AA13 indicated that the highest biomass and biological activities were obtained by utilizing the glycerol and peptone as carbon and nitrogen sources, respectively, with pH 7.0 and incubation temperature of 30°C. Two bioactive spots were detected by analysis of the ethyl acetate extract by thin-layer chromatography (TLC) and bioautography analyses. Among these bioactive compounds (antibiotics), a complex AA13-B that showed the interesting antifungal activity, was selected and purified by high performance liquid chromatography (HPLC), which indicated the presence of three peaks. Interestingly, the infrared spectroscopy (IR) studies showed that the molecule AA13-B2 contain an aromatic ring substituted by aliphatic chains. However, the investigations which determine the structure of the antifungal molecule are in progress.

The objective of our work is to assess the quality of the dam Foum El-Khanga (east of Algéria) monthly during the year 2014. This study planned to make a physico-chemical characterization to highlight several parameters which come into play the determination of the quality of this water such as: temperature; pH; conductivity; turbidity; dissolved oxygen; title hydrotimetric; calcium; magnesium; title alcalimetric complet; nitrate; nitrite; ammoniacal nitrogen; sulfate; chloride; bicarbonate; phosphate; iron; biological oxygen demand (BOD) and chemical oxygen demands (COD). The results of physico-chemical analysis show that the water of this dam is characterized by a significant mineralization as indicated by high values of electrical conductivity and chloride. The results of principal component analysis (PCA) clearly showed a stronger relation between the hot season and temperature. However, the cold season was strongly correlated with mineralization and pollution parameters. European Scientific Journal April 2017 edition Vol.13, No.12 ISSN: 1857 -7881 (Print) e -ISSN 1857-7431 259 RésuméL'objectif de notre travail est d'évaluer la qualité des eaux du barrage Foum El-Khanga (est de l'Algérie) mensuellement durant l'année 2014. Cette étude a envisagé de faire une caractérisation physico-chimique pour mettre en évidence plusieurs paramètres qui entrent en jeu dans la détermination de la qualité de cette eau tel que : la température ; le pH ; la conductivité ; la turbidité ; l'oxygène dissous ; le titre hydrotimétrique ; le calcium ; le magnésium ; le titre alcalimétrique complet ; le nitrate ; le nitrite ; l'azote ammoniacal ; le sulfate ; le chlorure ; le bicarbonate ; le phosphate ; le fer ; la demande biologique en oxygène (DBO5) et la demande chimique en oxygène (DCO). Les résultats des analyses physico-chimiques montrent que les eaux de ce barrage sont caractérisées par une minéralisation naturelle importante comme l'indique les valeurs élevées de la conductivité électrique et des chlorures. Les résultats de l'analyse en composantes principales (ACP) ont clairement montré une forte corrélation entre la saison chaude et la température. En revanche, la saison froide est fortement corrélée avec les paramètres de minéralisation et de pollution.