Background: Pressure ulcer reconstruction remains a great challenge for plastic surgeons because of their high postoperative complication and recurrence rates. Commonly these ulcers are reconstructed with random pattern flaps or myocutaneous flaps. Gluteal artery perforator flaps have evolved in the last few decades and became popular in reconstructing pressure ulcers in the gluteal region because they preserve the gluteal muscle, allowing for revision in cases of recurrence.Objective: To evaluate the use of gluteal artery perforator flaps in reconstructing pressure ulcers of the gluteal region as regards aesthetic outcome, postoperative complications and patients' psychological satisfaction.Patients and Methods: Our study was conducted on 15 patients presented with grade IV pressure ulcers in the gluteal region, in which their ulcers were reconstructed with gluteal artery perforator flaps.Results: Twelve (80%) patients healed eventually without major complications. Two (13.3%) patients had wound edge dehiscence, and only one (6.7%) patient had a donor site wide scar. Patients were evaluated as regards aesthetic outcomes and patients' psychological satisfaction, and the overall results were satisfactory. Conclusion:The superior and inferior gluteal artery perforator flaps, with their safe anatomical basis, less morbidity and versatility in designs, are reliable and effective alternatives in reconstructing pressure ulcers of the gluteal region.