Background: Cohesion of interendothelial junctions is maintained by the connections existing between the VE-cadherin⅐catenin complex and the actin cytoskeleton. Results: By interacting with ␣-catenin, the actin-binding protein EPLIN (epithelial protein lost in neoplasm) facilitates the recruitment of vinculin. Conclusion:The EPLIN␣-catenin link provides a mechanosensory machinery by acting as a tension transmitter. Significance: By anchoring the VE-cadherin⅐catenin complex to F-actin, EPLIN strengthens interendothelial junctions.