Introduction: Aspirin has justifiably been called the first miracle drug. In this article, we highlight the history of Aspirin, a novel mechanism of action, and its use in cardiovascular and other diseases. Also included is a brief statement of emerging new applications. Objective: We highlight principal mechanisms by which Aspirin inhibits acute inflammation and alters platelet-biology; therefore, hypothesized that Aspirin might prove highly beneficial as a novel therapeutic drug for combating severe acute inflammation and thrombosis associated with the cytokine storm in COVID -19 patients. The communiqué also suggests possible strategies for maximizing the gain of Aspirin as a wonder-drug of the future. Discussion: Interestingly, some fascinating studies demonstrated Aspirin's superior benefits with dangerous side effects. Aspirin inhibits COX-1 (cyclooxygenase-1). Its impact on COX-2 is more delicate because it “turns off” COX-2's production of prostaglandins but “switches on” the enzymatic ability to produce novel protective lipid mediators. The established mechanism of action of Aspirin is the inhibition of prostaglandin synthesis. However, further evidence showed that aspirin-elicited nitric oxide exerts anti-inflammatory effects in the microcirculation by inhibiting leukocyte– endothelium interactions. Interestingly, aspirin-triggered lipoxin formation may provide a novel mechanism underlying Aspirin's clinical benefits. Interestingly, Aspirin reduces the risk of a cardiovascular event by about 30 percent. Also, Aspirin has been associated with a reduced risk of colorectal cancer, and possibly a few other digestive tract cancers. Conclusion: The current emerging interest is to conduct further study to provide evidence for Aspirin as the novel therapeutic drug for combating severe acute inflammation and thrombosis associated with the cytokine storm in COVID-19 patients. Besides, the most wanted is The RECOVERY II (Randomized Evaluation of COVID-19 Therapy II) trial to be established as a randomized clinical trial to test the effectiveness of low-dose Aspirin as an anti-inflammatory and antithrombotic treatment in COVID-19 patients.

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One of the challenges plaguing the health of people is the effect of chronic diseases. Life expectancy of people has continued to be at stake due to the emergence of chronic diseases. The centers for public health in various countries have raised concern that there is a need for urgent intervention to address this challenge. Self-management is the key to a healthy life and healthy aging. According to the World Health Organization (WHO), lifespan management could play an important role in preventative measures of hereditary diseases, reduce mortality rates, and act as motivating factors to human beings in general. Life span is the duration of existence of an individual or the amount of time that a person or animal lives according to Cambridge dictionary and this could be improved. There are various measures that have been scientifically proven to improve lifespan management such as calorie reduction, good nutrition, regular exercise, weight reduction, and healthy relationship. In conclusion, healthcare givers, doctors, and nurses should be able to learn that treatment is not the only medical process that can heal a patient. Lifespan management is an all-round process aimed at improving the health of a patient and if possible, a total restoration.

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