Over the past years, low birth weight (LBW) has been proven to be attributed to a wide variety of long-term morbidities, including hypertension. This study aimed to investigate the association between high-sensitivity C-reactive protein (hs-CRP) and blood pressure (BP) in children with a history of LBW appropriate for gestational age (LBW AGA), LBW small for gestational age (LBW SGA), and normal birth weight appropriate for gestational age (NBW AGA). The study cohort comprised children aged 9–12 years who were born in 2007–2010 at Prof. Dr. R. D. Kandou General Hospital Manado and resided in the city of Manado from March to August 2019. The children who met the inclusion criteria were evaluated for BP and hs-CRP level. A total of 120 children who met the inclusion criteria were enrolled in this study. Analysis for the association between LBW and NBW with systolic blood pressure (SBP) showed statistical significance (p=0.007). Linear regression analysis indicated a strongly significant influence of BW on serum hs-CRP level and SBP. Every 1 g increase in BW results in a decrease of serum hs-CRP level of 0.001 mg/L. Every 1 g increase in BW is attributed to 0.004 mmHg decrease in SBP. An increase in hs-CRP by 1 mg/L increases the SBP by 4.99 mmHg and DBP by 2.88 mmHg. LBW significantly correlates with hs-CRP level and higher SBP. A comprehensive education must be undertaken for the families who have children with LBW to reduce the risk of developing hypertension later in their life.

Latar belakang. Anak dengan riwayat berat lahir rendah (BLR) kecil masa kehamilan (KMK) memiliki peningkatan risiko menderita hipertensi dan gangguan kardiovaskular di kemudian hari. High sensitivity C-reactive protein (hs-CRP) memengaruhi kerusakan pembuluh darah yang mengakibatkan peningkatan tekanan darah. Tujuan. Menganalisis hubungan hs-CRP dengan berat lahir dan tekanan darah pada anak dengan riwayat BLR KMK. Metode. Penelitian dengan desain potong lintang dilakukan dari bulan Oktober -Desember 2018 di Manado. Kriteria inklusi adalah anak dengan riwayat BLR KMK, lahir pada tahun 2004-2009 di Rumah Sakit Umum Pusat Kandou, berdomisili di Manado, memiliki catatan medis lengkap, status gizi baik, dan mendapat persetujuan dari orang tua. Kriteria eksklusi adalah anak yang memiliki riwayat penyakit ginjal, sakit dan mengonsumsi obat-obatan dalam 2 minggu terakhir. Pengukuran Hs-CRP digunakan metode imunonephelometric dengan Dade Behring kit. Data dianalisis menggunakan korelasi Pearson dan uji regresi linier sederhana. Hasil. Total 40 anak dengan riwayat BLR KMK terdiri dari 16 anak laki-laki dan 24 anak perempuan. Rerata berat lahir adalah 2338,75 gram dan rerata kadar hs-CRP adalah 1,3158 mg/L. Terdapat hubungan negatif antara hs-CRP dan berat lahir (r=-0,275; p=0,043), hubungan positif antara hs-CRP dan tekanan darah sistolik (TDS) (r=0,559; p<0,0001), dan juga antara hs-CRP dengan tekanan darah diastolik (TDD) (r=0,451; p=0,002). Kesimpulan. Terdapat korelasi negatif antara hs-CRP dan berat lahir. Nilai hs-CRP yang tinggi berhubungan dengan TDS dan TDD yang lebih tinggi pada anak berusia 9 -14 tahun dengan riwayat BLR KMK. Sari Pediatri 2020;21(5):289-94Kata kunci: high sensitivity c-reactive protein, tekanan darah, berat lahir rendah, kecil masa kehamilan Background. Low birth weight (LBW) and small for gestational age (SGA) children have an increased risk of developing hypertension and cardiovascular diseases during adult life. High sensitivity C-Reactive Protein (hs-CRP) is associated with endothelial damage that will cause an increase in blood pressure. Objective. To analyze for a possible association between hs-CRP and blood pressure in children who were born low birth weight and small for gestational age. Methods. We conducted a cross-sectional study from October to December 2018. Inclusion criteria were children who were born LBW and SGA in 2004-2009 at Kandou General Hospital, resided in Manado, had complete medical records, good nutritional status, and parents consented to their participation. Exclusion criteria were children who had renal disease, sick and taking medications prior to enrollment. Hs-CRP was measured using immunonephelometric methods with The Dade Behring kit. Data were analyzed using Pearson correlation and simple linear regression test. Result. A total of 40 children with LBW and SGA history consisted of 16 boys and 24 girls. The mean birth weight is 2338.75 grams and the mean hs-CRP level is 1.3158 mg/L. There was a negative correlation between hs-CRP and birth weight (r = -0.275...