IntroductionCushing’s syndrome is a relatively rare condition that results from chronic hypercortisolism. This syndrome is characterized by the presence of various psychiatric manifestations that can accompany it at all its stages of evolution. They can either inaugurate the clinical picture, or appear during the course of the disease, as they can persist even after the resolution of the syndrome. of Cushing. Through a clinical vignette, we report a case of Cushing’s syndrome in a 52-year-old patient who presented with a picture of melancholic depression as part of a bipolar disorder and who had preceded the discovery of Cushing’s disease.Objectivesestablish the relationship between Cushing’s syndrome and bipolar disorder and identify the main pillars of care.MethodsIt was proposed to present the clinical case of a 52-year-old patient in whom psychiatric manifestations of the psychotic and thymic types preceded the discovery of Cushing’s disease, to recall the main psychiatric symptoms that can be encountered during such endocrine disorders and their possible entanglement with psychiatric pathologies.ResultsMrs. F. is 52 years old. married and mother of 3 children, without social security coverage for medullary carcinoma of the thyroid, having benefited from thyroidectomy with radiotherapy, admitted for treatment of paraneoplastic Cushing’s syndrome. The beginning of his troubles goes back to 6 months before his consultation with psychiatry. The initial symptoms were typical of a progressive weight gain noticed by the entourage. There was the installation of thymic symptoms such as an elation of mood, self-esteem, multiple projects. One month before admission to the internal medicine department, the patient presented with a depressed mood, anhedonia , a disgust for life, and dark thoughts. She had stopped all drug treatment.Cushing’s disease is the most common cause of endogenous hypercortisolism (>85%). Corticotropic micro-adenomas , are the most frequently observed, i.e., in 90% of cases, and are sometimes not visible on magnetic resonance imaging . Its first-line treatment is neurosurgical with trans-sphenoidal excision. In its second intention, it uses drugs whose targets are pituitary or adrenal, as well as radiotherapy.Conclusionswe present the case of a patient with a picture of bipolar mood disorder and Cushing’s disease. Thymic and psychotic psychiatric symptoms preceded the discovery of endocrine disease whose symptoms were not apparent at first. The hypotheses of comorbidity or rather of the inauguration of the endocrine disease by a psychiatric picture, in particular bipolar mood disorder, remain advanced and the limits betweenDisclosure of InterestNone Declared

Introduction: The prevalence of heroin use in Morocco was 0.02%. These figures were higher in the northern region of Morocco. The personality disorder represented a difficulty in the management of the heroin addicted patient. The aim of this study was to show that personality disorders were often comorbid with heroin addiction and to specify the predominant pathological personalities in the Moroccan population. Material and methods:A descriptive cross-sectional study in a population of 171 subjects.Collection of sociodemographic and clinical data by form.Scale:Personality Diagnostic Questionnaire (PDQ - 4+)Statistical analysis: Excel 2016, SPSS 2021: Student test, ANOVA and CHI-2 Results:Sample of 171 patients with 97.7% of male patients and average age of 43,59.Half of the population (48.5%) had only primary education80.7% never received psychiatric care.The average number of incarcerations in our population was 3,96The predominant personality disorders were borderline and antisocial personality disorder respectively.Statistically significant relationship between borderline personality disorder and psychiatric history and the number of hospitalizations in psychiatric units.Statistically significant relationship between the number of incarcerations and antisocial personality disorder. Conclusion: Heroin addicts in Morocco suffered from social instability, strong cannabis dependence, delinquency and frequent judicial recidivism. The most frequent personality disorders were borderline and antisocial. However, the causal link between the personality disorder and the addiction remained to be defined.

In addition to being a public physicalhealth emergency, Coronavirus disease 2019 (COVID-19) affected global mental health as cases increased. Objectives: The aim of thisstudyis to determine the psychologicalimpact on mental well-being and associatedriskfactorsamonghealthcareworkers. Researchmethodology: a cross-sectional studyamongMoroccanhealthcareworkerswasconducted to measureprevalence rates of symptoms of anxiety,depression, burn out and theirassociatedfactors, objectified by the Hospital Anxiety and DepressionScale(HADS), Maslach Burnout Inventory(MBI) and a questionnaire, respectively. Results:Symptoms of anxiety, depression, and emotional exhaustion werereported by 38.5%, 28.1% and 85.4% of the 96 respondents,respectively. Beingyoung and having a psychiatrichistorywereassociatedwith more anxietysymptomatology. Whileworking in the intensive care unit, feeling obliged to work in the covid circuit, living withfamilywereassociatedwithdepressionsymptoms. The factorsstatisticallyrelated to burnout wereyears of work, having an organichistory working in intensive care unit and consideringthat the number of staff isinsufficient, that the communication withtheircolleagues and superiorsisinadequate and that the training theyhadbeforejoining covid was not sufficient Conclusion: The COVID-19 pandemichad a high impact on the mental well-being of healthcareworkersincreasing the risk of dropout and compromisescontinuity of care. Efforts must be made to optimize working conditions and reduceworkload.