Background Morocco was affected, as were other countries, by the coronavirus disease 2019 (COVID-19) pandemic. Many risk factors of COVID-19 severity have been described, but data on infected patients in North Africa are limited. We aimed to explore the predictive factors of disease severity in COVID-19 patients in a tertiary hospital in Casablanca. Methods In this single-center, retrospective, observational study, we included all adult patients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, admitted to Sheikh Khalifa International University Hospital in Casablanca between March 18 and May 20, 2020. Patients were separated into two groups: Non-severe patients were those with mild or moderate forms of COVID-19, and severe patients were those admitted to the intensive care unit (ICU) who had one of the following signs-respiratory rate > 30 breaths/min; oxygen saturation < 93% on room air; acute respiratory distress syndrome (ARDS); or required mechanical ventilation. Demographic, clinical, laboratory data, and outcomes were reviewed. We used univariable and multivariable logistic regression to explore predictive factors of severity. Results We reported 134 patients with confirmed SARS-CoV-2 infection. The median age was 53 years (interquartile range [IQR], 36-64), and 73 (54.5%) were men. Eighty-nine non-severe patients (66.4%) were admitted to single bedrooms, and 45 (33.6%) were placed in the ICU. The median time from illness onset to hospital admission was seven days (IQR, 3.0-7.2). Ninety-nine patients (74%) were admitted directly to the hospital, and 35 (26%) were transferred from other structures. Also, 68 patients (65.4%) were infected in clusters. Of the 134 patients, 61 (45.5%) had comorbidities, such as hypertension (n = 36; 26.9%), diabetes (n = 19; 14.2%), and coronary heart disease (n = 16; 11.9%). The most frequent symptoms were fever (n = 61; 45.5%), dry cough (n = 59; 44%), and dyspnea (n = 39; 29%). A total of 127 patients received hydroxychloroquine and azithromycin (95%). Eleven critical cases received lopinavir/ritonavir (8.2%). Five patients received tocilizumab (3.7%). We reported 13 ARDS cases in ICU patients (29%), eight with acute kidney injury (17.8%), and four thromboembolic events (8.8%). Fourteen ICU patients (31.1%) died at 28 days. In univariable analysis, older men with one or more comorbidities, infection in a cluster, chest scan with the COVID-19 Reporting and Data System (CO-RADS) 5, lymphopenia, high rates of ferritin, C-reactive protein (CRP), D-dimer, and lactate dehydrogenase were associated with severe forms of COVID-19. Multivariable logistic regression model founded increasing odds of severity associated with older age (odds ratio [OR] 1.05, 95% confidence interval [

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Chimeric antigen receptor (CAR) T-cells represent a new genetically engineered cell-based immunotherapy tool against cancer. The use of CAR T-cells has revolutionized the therapeutic approach for hematological malignancies. Unfortunately, there is a long way to go before this treatment can be developed for solid tumors, including colorectal cancer. CAR T-cell therapy for colorectal cancer is still in its early stages, and clinical data are scarce. Major limitations of this therapy include high toxicity, relapses, and an impermeable tumor microenvironment for CAR T-cell therapy in colorectal cancer. In this review, we summarize current knowledge, highlight challenges, and discuss perspectives regarding CAR T-cell therapy in colorectal cancer.

Objective: A multicentric cross sectional study conducted in 2021, and carried out in provincial hospital Mensour Bernoussi, provincial hospital Sidi Othman in the region of Casablanca settat and provincial hospital Mohammed V health center Saada and health center Jamaat Shaim in the region of marrakech safi . the first objective is to determine the key elements impacting the anemia ,the second , consist to see the role of the diversity food and the third one , the impact of iron supplementation on anemic and non anemic women. Methodology: All pregnant women (503) attending to the 5 heath structure in the region Casablanca-Settat and Marrakech-Safi and have CBC result . a anonymous questionnary was conducted including CBC result , socio demographic data , (antenatal care ) ANC follow up , iron supplementation , common signs and symptoms of anemia , complication during pregnancy and a total recall and modified MDDW and frequency at food consumption of 1 month . the data was analyzed using the Jamovi database . Result: The mean and standard deviation age of participant was for the non anemic pregnant women 28.9+/- 6.21 years versus for the anemic pregnant women 26.6 +/- 6.26 years .The age range of the population was 33 years from 15 years to 48 years old . most anemic pregnant had a hypochromic 74.3% microcytic type of anemia, 92.9% where housewife and lower monthly income compare to the none anemic pregnant women , also the mean gestity and parity of the pregnant women was 2.55+/-1.44 and 2.14+/-1.37 respectively, a 85.9% patient was followed during pregnancy, a higher level of 75.5% of patient was on iron supplementation and there was significative result concerning anemia signs ( especially pallor , hair loss and headache). Furthermore, using the longitudinal bivaried and multivaried regression revealed that the anemic pregnant women were respectively less exposed the older they are (reference (15-23 years) 28-32 years (p=0.045 OR=19.380 IC95%[1.01-3.706]) and 33-48 years (p=0.005 OR=27.307 IC95% [1.34-5.527]) ), the followed up during the pregnancy reduces significative the risk of anemia (reference (yes) no p=0.005 OR=0.2409 IC95%[0.08839-0.657]), also the consumption of coffee/coffee with milk increased the risk. (Reference (yes) no p=0.020 OR=17.821 IC95%=[1.10-2.879]).