Background: Intestinal expression of peptide absorption transporter (PepT1)/Slc15a1 exhibits circadian oscillation, but the mechanism is unknown. Results: During the daily feeding cycle, bile acids accumulated in intestinal cells, thereby suppressing PPAR␣-mediated expression of PepT1/Slc15a1. Conclusion: Time-dependent suppression of PPAR␣ activity by bile acids underlies circadian expression of PepT1/Slc15a1. Significance: Bile acids cause circadian change in the intestinal absorption of peptides.
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