Background: Multiparametric magnetic resonance imaging (mpMRI) of prostate is the radiological investigation of choice for the evaluation of prostatic tumors. Aims and Objectives: The aim of the present study was to evaluate the efficacy of mpMRI using PIRADS 2.1 grading and apparent diffusion coefficient (ADC) values as a non-invasive investigation in the detection of prostatic tumors and to correlate PIRADS grade and ADC values with Gleason score of prostate cancer (prostate Ca). Materials and Methods: Fifty patients above the age of 50 years presenting with signs and symptoms of prostate Ca were enrolled for the study. All patients were subjected to the mpMRI including ADC values and then all underwent transrectal ultrasound-guided biopsies. The post-biopsy Gleason score was correlated with PIRADS grading and ADC values followed by statistical correlation. Results: There was a positive linear association between PIRADS score and serum prostate-specific antigen levels (+0.433) and inverse relationship between mean tumor ADC values and Gleason score with correlation coefficient of −0.846 (P<0.001). There was a positive linear association between the PI-RADS score and Gleason score (correlation coefficient of +0.739 with P<0.001). In addition, the positive predictive value of mpMRI was 78.79%, while the negative predictive value was 84.34%. Conclusion: Our study concludes that mpMRI with PIRADS grading including ADC values assists in targeting the appropriate biopsy site for better characterization of the prostate Ca as it correlates well with the Gleason score.

INTRODUCTION- To determine the optimal time to safely deliver a baby prematurely due to various clinical situations, it is crucial to accurately assess fetal lung maturity. Sonography which is a non-invasive technique for evaluating fetal lung maturity can be useful in predicting risk for developing neonatal respiratory distress as compared to amniocentesis which is an invasive procedure with associated risks. AIM - Purpose of this study was to determine if fetal main pulmonary artery doppler can play a role in predicting the risk of developing respiratory distress syndrome in neonates. MATERIAL AND METHODS – The participants in this prospective cross-sectional study were 75 pregnant women with gestational ages ranging from 34weeks to 36 weeks +6 days. Ultrasound doppler examination was conducted and peak systolic velocity (PSV), Systolic /Diastolic ratio, pulsatility index, resistive index were measured and acceleration time/ejection time ratio was calculated for the fetal main pulmonary artery. Diagnostic accuracy of these values was tested for predicting neonatal respiratory distress. RESULT - Of the 75 fetuses included in the study, 15 (20%) showed some signs of neonatal respiratory distress syndrome (RDS). The Acceleration time/Ejection time (AT/ET) ratio in fetal pulmonary artery correlated significantly with development of respiratory distress syndrome in neonates (P=0.001). Fetuses with respiratory distress syndrome had higher Pulsatility Index and Resistive Index values, while their AT/ET ratio was low. AT/ET was found to predict respiratory distress development with a cutoff value of 0.30 (sensitivity: 98.3 percent; specificity: 86.67 percent). Pulsatility Index and Resistive Index displayed lower sensitivity and specificity than AT/ET ratio. CONCLUSION- The fetal main pulmonary artery AT/ET ratio has a high sensitivity and specificity for predicting the development of neonatal respiratory distress syndrome. Thus, we recommend that a fetus with an AT/ET ratio of <0.30 be delivered in a facility with good neonatal care.