Introduction:  Ovarian cancer is one of the leading causes of cancer death in women globally. The objective of this study was to determine the correlation and the association between age, stage, histopathology, grade, ascites, tumor residual, CA-125 level, and type of surgery on recurrence, disease-free survival, overall survival and mortality of epithelial ovarian cancer patients. Methods: An analytical retrospective study using medical records and interviews of epithelial ovarian cancer patients was conducted in Dr. Soetomo Hospital. The study included the data from January 2016-December 2020. Kaplan-Meier and log-rank test were used to assess the factors associated with disease-free survival (DFS) and overall survival (OS). Results: A total of 358 patients with epithelial ovarian cancer from 2016 to 2020 were included in the study of which 153 of recurrence cases. Clinicopathological factors that correlated with disease-free survival were stage, histopathology, grade, ascites, tumor residual, CA-125, and type of surgery (p<0.05). The factors that correlated with overall survival were stage, histopathology, grade, ascites, residual tumor, and CA-125 value (p<0.05). The most significant factors associated with recurrence and mortality were stage, grade, and ascites. Stage II and III had an HR (hazard ratio) of 1.9 and 2.1 for recurrence compared to stage I, respectively. Grade II and III patients had HRs of 2.1, and 3.4 for recurrence compared to stage I, respectively. The presence of ascites had an HR of 1.5 compared to those had no ascites. Stage III had an HR of 1.9 for mortality compared to stage I, respectively. Grade II and III patients had HRs of 3.6, and 5.0 for death compared to stage I, respectively. The presence of ascites had an HR of 1.6 compared to patients with no ascites. Compared to serous type, those patients with mucinous and clear cell had HR of 1.8 and 3.1 for mortality, respectively Conclusion: Stage, grade, and ascites were the most significant factors in the incidence of recurrence and mortality of epithelial ovarian cancer.

Background: As of March 11, 2020, the number of confirmed cases in China had reached 80,955 with the death toll reaching 3,162. So far, Covid-19 tends to infect people who have comorbid diseases such as heart disease, diabetes mellitus, cancer and chronic respiratory diseases as well as people over 60 years of age. Several cases of Covid-19 have also been reported in pregnant women. Method: Radiographic technologies and tools including chest X-Ray and Computed Tomography (CT) are applied for initial screening and the follow-up because they provide detailed diagnoses with specific pathological features for staging and treatment settings. Not infrequently cases of Covid-19 are found in pregnant women because during pregnancy women’s condition becomes very vulnerable to infection with pneumonia pathogens due to physiological changes during pregnancy that result in a decrease in the immune system. Although the clinical symptoms are the same as for non-pregnant women and there are no aggravating factors, pregnant women are prone to hypoxia. Results: Chest x-ray (CXR) is a radiographic projection tool that can help diagnose conditions or abnormalities in the thoracic cavity. Due to the spread of Covid-19, it is important to recognize the common Covid-19 imaging findings and the abnormal pneumonia that occurs over time on CXR results. CXR can be used to diagnose patients with acute respiratory distress as the first line of evaluation for Covid-19 patients 19. Conclusion: CXR can be a screening modality in Covid-19 patients including pregnant women. However, it is necessary to keep in mind that the CXR examination can have an impact on the fetus. Even though the risk is small, pregnant women who will undergo a Covid-19 examination or evaluation need special attention. In addition, it is necessary to consider other examinations that can be carried out especially on pregnant women, which do not have the effect of radiation

Background: Achondroplasia is a rare genetic disease of bone growth with an incidence of 1:20,000 live births which is characterized by short stature disproportionate body, shortening of long bones, macrocephaly, and kyphoscoliosis. While pseudoachondroplasia is caused by an autosomal dominant mutation in the cartilage oligomeric matrix protein (COMP). Due to the rarity of this condition and its adverse impact on the obstetrical outcome, we find it interesting to report two cases of achondroplasia and pseudoachondroplasia with pregnancy. Case description: The first case was a 24-year-old woman with achondroplasia (patient's height was 116 cm) primigravida, who was referred at her 36-37 weeks of gestation. Ultrasound examination of the fetus revealed micromelia skeletal dysplasia. At 37-38 weeks of gestation, the patient underwent a cesarean section under the subarachnoid block (SAB) regional anesthesia because of the complication of cephalopelvic disproportion (CPD). The baby had a relatively large head circumference, frontal bossing, disproportionate short limbs, and trident hand appearance which is pathognomonic of achondroplasia. The second case was a 26-year-old woman with pseudoachondroplasia (patient's height was 127 cm) multigravida with a history of one abortion, who was referred at her 35-36 weeks of gestation. The patient underwent elective cesarean section with SAB regional anesthesia and the baby looked physically not inheriting maternal abnormalities. Conclusion: Achondroplasia increases maternal and fetal obstetric complications; thus, requiring prenatal counseling, comprehensive risk evaluation, and multidisciplinary team management of anesthesia, obstetrics, and neonatology.