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Background-Theoretically, autologous serum eye drops (AS) have a potential advantage over traditional therapies based on the assumption that AS serve not only as a lacrimal substitute to provide lubrication, but also contain other biochemical components mimicking natural tears more closely. The application of AS in dry eye treatment has gained popularity as a second-line therapy in the treatment of dry eye. Published studies on the subject indicate that autologous serum could be an effective treatment for dry eye.Objectives-To evaluate the efficacy and safety of AS compared to artificial tears for treating dry eye.Search methods-We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (

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