Objective: To compare the effects of premedication with intravenous paracetamol versus ketorolac, in decreasing intraoperative anesthetic and postoperative opioid analgesics requirements in patients undergoing laparoscopic cholecystectomy. Method: To be determined intraoperative opioid requirements, pain and analgesic requirements in the postoperative period in 100 healthy patients undergoing laparoscopic cholecystectomy. The selection was in two groups: group 1: premedicated with paracetamol and group 2: with ketorolac, both administered intravenously 30 minutes prior to surgery. Results: There weren´t statistically significant differences between groups with respect to intraoperative remifentanil consumption (group 1: 0.0739 ± 0.016, group 2: 0.0741 ± 0.018). The number of patients in group 2 had values of VAS> 4 points (22.4%) was lower than in group 1 (28.6%), but without statistically significant difference. Of the patients who merited reinforcements postoperative opioids, most merited a single reinforcement and application of analgesics during hospitalization prevailed between 3 and 12 hours, without significant differences between groups. No adverse effects were observed in the study sample. Conclusion: Paracetamol 1g IV placed preoperatively decreased anesthetic requirements and the need for postoperative analgesics, similar to preoperative administration of ketorolac 30 mg IV.