<b><i>Background:</i></b> Directional deep brain stimulation (DBS) enlarges the therapeutic window by increasing side-effect thresholds and improving clinical benefits. To determine the optimal stimulation settings and interpret clinical observations, knowledge of the lead orientation in relation to the patient’s anatomy is required. <b><i>Objective:</i></b> To determine if directional leads remain in a fixed orientation after implantation or whether orientation changes over time. <b><i>Method:</i></b> Clinical records of 187 patients with directional DBS electrodes were screened for CT scans in addition to the routine postoperative CT. The orientation angle of each electrode at a specific point in time was reconstructed from CT artifacts using the DiODe algorithm implemented in Lead-DBS. The orientation angles over time were compared with the originally measured orientations from the routine postoperative CT. <b><i>Results:</i></b> Multiple CT scans were identified in 18 patients and the constancy of the orientation angle was determined for 29 leads at 48 points in time. The median time difference between the observations and the routine postoperative CT scan was 82 (range 1–811) days. The mean difference of the orientation angles compared to the initial measurement was –1.1 ± 3.9° (range –7.6 to 8.7°). Linear regression showed no relevant drift of the absolute value of the orientation angle over time (0.8°/year, adjusted <i>R</i>²: 0.040, <i>p</i> = 0.093). <b><i>Conclusion:</i></b> The orientation of directional leads was stable and showed no clinically relevant changes either in the first weeks after implantation or over longer periods of time.