biotalar fusion is considered to be the standard treatment for end-stage post-traumatic arthritis of the ankle. We report a retrospective, objective long-term study of the quality of life of 17 patients with 18 arthrodeses of the ankle, over a period of more than 20 years. We looked particularly for correlation between clinical and radiological signs of osteoarthritis in adjoining joints. At serial physical examinations, clinical grades were awarded according to the Olerud Molander Ankle (OMA) score. Any degree of degenerative change in the adjoining joints was recorded on standing radiographs. Patients filled out a SF-36 Health Survey form. Subjectively, 50% of patients were not handicapped in the performance of daily activities and 44% were in the same job as at the time of injury. At follow-up the mean OMA score was 59.4 points, the visual analogue scale was 1.99 and the radiological score was 2.7. The SF-36 for physical function, emotional disturbance and bodily pain revealed significant deficits. There was a significant correlation between the OMA and the radiological score (p = 0.05), and between the clinical and the SF-36 score (p = 0.01), but no significant correlation between the radiological score and the SF-36 score. Arthrodesis of the ankle leads to deficits in the functional outcome, to limitations in the activities of daily living and to radiological changes in the adjoining joints. The clinical outcome score correlates closely with the SF-36 score.

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The results provide strong evidence for a significant impact of synovial-derived MMPs on cartilage destruction in OA. In this context, fibroblasts present in the synovial fluid appeared to play an outstanding role.

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This study compared the overall outcome after salvage revision total knee arthroplasty using hinged and nonhinged designs. We followed 26 total knee arthroplasties for an average of 20.4 months. The average age was 68.5 years. All patients had a salvage situation secondary to excessive bone loss, enlarged flexion gap, collateral ligament insufficiency, or extensor mechanism insufficiency. Ten patients received a hinged implant after an average of 2.8 prior total knee replacements. Sixteen patients received nonhinged constrained implants after an average of 3.4 prior total knee replacements. The outcome was evaluated using the Hospital for Special Surgery Score (HSS), the Knee Society Score (KSS), the Visual Analogue Scale for pain (VAS), the Tegner Activity Score, the Patella Score, and the Short Form-36 Health Survey (SF-36). There was a statistically significant difference in flexion range of motion between hinged and nonhinged designs (96.5 degrees vs. 107.5 degrees ) but not in HSS, KSS, VAS, Tegner Activity Score, or Patella Score. Patients with hinged and nonhinged prostheses had significantly lower scores than an age-matched normal population in physical functioning, role limitations, and bodily pain on the SF-36 survey. However, patients with a hinged implant had no statistically significant difference compared to controls in the mental component summary. In salvage total knee arthroplasty the implant design does not significantly affect the overall functional outcome. However, patients with a hinged implant had significant better scores in the mental components of the SF36 quality-of-life assessment.