Some symptoms of schizophrenia might be present before full-blown psychosis, so white matter changes must be studied both in individuals with emerging psychosis and chronic schizophrenia. A total of 86 patients—12 ultra-high risk of psychosis (UHR), 20 first episode psychosis (FEP), 54 chronic schizophrenia (CS), and 33 healthy controls (HC)—underwent psychiatric examination and diffusion tensor imaging (DTI) in a 3-Tesla MRI scanner. We assessed fractional anisotropy (FA) and mean diffusivity (MD) of the superior longitudinal fasciculus (SLF) and inferior longitudinal fasciculus (ILS). We found that CS patients had lower FA than FEP patients (p = 0.025) and HC (p = 0.088), and higher MD than HC (p = 0.037) in the right SLF. In the CS group, we found positive correlations of MD in both right ILF (rho = 0.39, p < 0.05) and SLF (rho = 0.43, p < 0.01) with disorganization symptoms, as well as negative correlation of FA in the right ILF with disorganization symptoms (rho = −0.43, p < 0.05). Among UHR individuals, we found significant negative correlations between MD in the left ILF and negative (r = −0.74, p < 0.05) and general symptoms (r = −0.77, p < 0.05). However promising, these findings should be treated as preliminary, and further research must verify whether they can be treated as potential biomarkers of psychosis.

Background: Although the relationship between shyness and self-esteem is well described in the psychological literature, far less is known about the potential mechanisms that underlie this association. The main goal of the current work is to verify whether self-presentation acts as a mediating variable between both constructs. Methods: The study was carried out among 198 adults. The Revised Cheek and Buss Shyness Scale, the Rosenberg Self-Esteem Scale, and the Self-Presentation Style Questionnaire were applied. Results: A large and positive correlation coefficient was observed between the following variables: (1) self-esteem/self-promotion; (2) shyness/self-deprecation. All other variables correlated negatively: (1) shyness/self-esteem; (2) shyness/self-promotion; (3) self-esteem/self-deprecation; (4) self-promotion/self-deprecation. Moreover, both self-promotion and self-deprecation acted as mediators between life satisfaction and self-esteem. Conclusion: The outcomes of the present study show a new mediating aspect for the direct relationship between shyness and self-esteem in the form of two styles of self-presentation. The results indicate that the tendency of shy people to avoid others can have a lower effect on their overall sense of self-esteem when they try to present themselves in a clearly favorable light. By contrast, shyness may have a stronger impact on their sense of self-worth when they present themselves as helpless, unsure, and incompetent.

There is a paucity of reports examining the relationship between the integrity of the corpus callosum (CC) and different aspects of cognitive functioning in patients with first-episode (FES) and chronic schizophrenia (CS) simultaneously; furthermore, what results exist are inconclusive. We used diffusion tensor imaging tractography to investigate differences in integrity in five regions of the CC between FES, CS, and healthy controls (HC). Additionally, we analyzed correlations between these regions’ integrity and working memory, planning, and speed of processing. Eighteen patients with FES, 55 patients with CS, and 30 HC took part in the study. We assessed cognitive functions with four tasks from Measurement and Treatment Research to Improve Cognition in Schizophrenia. Patients with CS showed lower fractional anisotropy (FA) in Region 5 (statistical trend) and higher mean diffusivity (MD) in Regions 4 and 5 than HC, and patients with FES had higher MD in Region 3 (statistical trend) than HC. Both clinical groups performed worse on working memory and speed of processing tasks than HC, and patients with CS scored worse than HC on independent planning, and worse than FES and HC on dependent planning. Moreover, in patients with CS, MD in Region 3 was correlated with verbal working memory. Our results suggest that patients with FES and CS are characterized by impaired integrity of the middle and posterior CC, respectively. We confirmed that both clinical groups have cognitive impairments. Moreover, the integrity of the middle CC may influence planning in patients with CS.