RESULTSIn Cohort 1, CFR was significantly lower (2.12AE0.79 vs. 2.56AE0.63; p<0.001) and HMR was significantly higher (2.61AE1.22 vs. 2.31AE0.89; p¼0.04) in vessels with CAD than the vessels without CAD, within the same patient. mMR was equivalent in obstructed and nonobstructed vessels: 1.54AE0.77 vs. 1.53AE0.57; p¼0.90. Cohort 2 confirmed these findings, showing a significant relationship for CFR and HMR with diameter stenosis % (b¼-0.013, 95%CI [-0.016 to -0.010]; p<0.001 for CFR and b¼0.008, 95%CI [0.004 to 0.011]; p<0.001 for HMR per 1%), while mMR was independent of diameter stenosis % (b¼0.002, 95%CI [-0.001 to 0.004] per 1%; p¼0.15). No association was found between mMR and any of the risk factors for cardiovascular disease.CONCLUSION Minimal microvascular resistance is a novel index to assess MCD. mMR possesses the unique property that it does not depend on the presence of CAD, unlike CFR and HMR which are currently used to assess MCD.
CATEGORIES IMAGING: FFR and Physiologic Lesion Assessment
TCT-525Initial experience with the use of fractional flow reserve in percutaneous intervention of transplant renal artery stenosis
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