Multiple Sclerosis (MS) is a disease affecting millions of people worldwide caused by an abnormal immune response that deteriorates the myelin sheath encapsulating neurons, drastically impairing neural communication. Currently, no tests can guarantee the diagnosis of MS until symptoms become severe. Early-stage diagnosis for MS is beneficial as it allows for an early start to treatment that slows its progression. This project aimed to analyze data from gene expression studies and identify commonly differentially expressed genes (DEGs) in the blood of MS patients. 183 overexpressed DEGs were identified and a diagram depicting protein interactions was generated with STRINGDB. Cytoscape was used to analyze interactions and recognize Hub genes. Further analysis on PANTHER showed that the biological processes of "tRNA aminoacylation for protein translation" and "mitochondrial translational elongation" were enriched in the upregulated DEGs. Furthermore, processes directly connected to the immune system such as the "Fc receptor signaling pathway" and "antigen processing and presentation of peptide antigen" were overrepresented. The identified Hub genes RPS27A, NSA2, RPS15A, and POLR2C are potential biomarkers for MS and warrant further study. Overall, this study could provide greater insight into the molecular pathways of MS and evidence to support which genes are overexpressed in MS.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.