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Groundwater quality is a function of the enclosing aquifer materials and/or human influences. Therefore, frequent water quality surveillance is essential as the subsurface resource is a main source of water supply in Santchou, Cameroon Western Highlands. In order to carry out the inquiries, 24 groundwater samples were collected during the wet period (July 2020) as well as during the dry season (February 2021) from springs, a borehole and hand-dug wells. The water samples were tested in the field for pH, electrical conductivity and turbidity, while two separate water samples were obtained from each sampling point for chemical and bacteriological parameters in the laboratory. The main results revealed that the studied groundwater samples are weakly mineralised, with a slightly acidic pH. The major ionic constituents of the sampled sources were within acceptable limits prescribed by the World Health Organisation except for Mg 2+ and Clthat were noted in excess of the recommended values at some sites. Piper plot indicated that the water is essentially of Na-K-Cl-SO 4 type while the Gibbs diagram showed that hydrochemistry was predominantly due to rock-weathering. SAR (sodium absorption ratio) values, Na % (sodium percentage) and TH (total hardness) revealed that the water is suitable for irrigational practices. Microbiological pollutants such as Enterobacteria, E. coli, Streptococcus spp, Salmonella spp, Shigella spp, Vibrio spp and Staphylococcus spp were noticed in the water samples, and hence consumers' health may be compromised if basic treatment methods like boiling and filtration are not performed before the water is used for drinking.