Myopia is one of the most relevant problems in pediatrics. One of the starting mechanisms of myopia is accommodation disorders. With an imbalance of autonomic innervation of the ciliary muscle, the process of accommodation is disrupted, which leads to the development and progression of myopia. The purpose of this study was to assess the features of vegetative homeostasis in teenagers with myopia. During the work, a survey was conducted among 300 teenagers of 15 years old, in schools of Yakutsk. The main group was 114 teenagers with myopia, the control group was 186 adolescents without refraction disorders. According to cardiorhythmography, teenagers with myopias have a high level of centralization of heart rate management, a relatively high level of activity of the sympathetic department of the autonomic nervous system and low activity indicators of the parasympathetic department of the autonomic nervous system. Sympathicotonia was much more common in young men than in girls. Sympathicotonia, functional tension and overvoltage, increased cardiovascular response to an orthostatic probe, excessive and insufficient, and paradoxical vegetative provision are characteristic of teenagers with myopia. The results showed that teenagers with myopia of both genders have autonomic nervous system imbalance.