Epidemiological outcome studies have shown that infections caused by drug-resistant P. aeruginosa are associated with significant increases in morbidity. To determine resistance pattern of Pseudomonas aeruginosa isolated from asymptomatic bacteriuric women attending antenatal clinic in a tertiary hospital in Makurdi, Central Nigeria. Twenty eight(28) Pseudomonas aeruginosa isolates from a total of 277different bacterial organisms,were plated on Mueller Hilton agar following standard microbiological protocols. And the disc diffusion method of Kirby Bauer was adopted for susceptibility testing. Results showed that most of the isolates were not susceptible to the inhibitory activities of clindamycin (96.4%), ceftriaxone (89.3%) and clarithromycin (89.3%) and susceptible at 100% to ofloxacin, perfloxacin and ciprofloxacin generally classified as the quinolones. Quinolones possess excellent activity invivo against enterobacteriaceae like P. aeruginosa amongst others.