Chronic hepatitis is major health problem that affect liver function with high morbidity and mortality in developing countries. Macerated liquorice root used since several decades as one of traditional drink in Egypt. We aimed in this study to evaluate the hepatoprotective effect of liquorice extract versus silymarin in chronic hepatitis rat model and explain the possible mechanism of hepatoprotection in such disease. To achieve our aim fifty male albino rats were used and divided into 5 equal groups, control group, chronic hepatitis group, chronic hepatitis group protected with liquorice extract, chronic hepatitis group protected with silymarin, normal group administrated liquorice extract. The results of the study exhibits the hepatoprotective effects of liquorice extract against chronic hepatitis as well as silymarin through there antiinflammatory and antioxidants mechanism.

Selenium nanoparticles have received wide attention because of their importance in nutrition compared to other forms of selenium used in food fortification. Within recent study, selenium nanoparticles (SeNPs) were prepared, characterized, and evaluated in albino rats to identify their hepatic protective effect against cyclophosphamide-induced hepatotoxicity. Fifty white albino rats were divided randomly into five groups. Group I was used as a negative control, group II was administrated daily dose of CP (5 mg/kg body weight/8 weeks) orally by gavage, group III were administrated SeNPs orally at a dose of (2 mg/kg body weight / 12 weeks) three times weekly. Group IV was administrated CP at a dose of (5 mg/kg body weight/8 weeks) daily orally then administrated SeNPs orally at a dose of (2 mg/kg body weight / 4 weeks) three times weekly. Group V (protected group) was administrated SeNPs orally at a dose of (2 mg/kg body weight/4 weeks) three times weekly, then administrated daily dose of CP (5 mg/kg body weight/8 weeks) orally with continuous administration of SeNPs till the end. Based on results obtained, CP administration in group II showed significant increase in serum liver enzymes activity (AST, ALT, and ALP), which was followed by a substantial significant decrease in serum albumin conc. and tissue antioxidants (GPx, SOD, and CAT) activity, with significant increase in cytokine levels (IL6, IL1β). Such biochemical changes were significantly improved by Nano-Se treatment, particularly in the protected rats. The current study found that Nano-Se reduces oxidative stress in liver tissue caused by CP administration.

The goal of this research was to see if using Cur-NPs could boost curcumin bioavailability and to see whether Cur-NPs could protect rats from Cp-induced hepatotoxicity. Five groups of fifty white albino rats were formed at random. Group I acted as negative control while group II received Cyclophosphamide daily dosage of (5 mg/kg body weight) via oral gavage for 8 weeks. Group III received Cur-NPs at a dosage of (20 mg/kg bw) 3 days a week via oral gavage for 4 weeks. Group IV received CP as group II and treated with Cur-NPs as group III for 4 weeks. Group V received Cur-NPs as protector, for 4 weeks before CP administration as group II with continuous administration with Cur-NPs till the end. At the end of the experiment, blood and tissue samples were obtained for biochemical, antioxidant enzyme, and cytokine level determination. According to the findings, giving CP to rats in group II increased serum liver function enzymes (ALT, AST, and ALP), which was followed by a substantial decrease in serum albumin conc. and tissue antioxidants (GPx, SOD, and CAT) activity, as well as increased levels of cytokines (IL-6, IL-1β). Cur-NPs treatment improved these biochemical changes dramatically, particularly in group These findings suggest that Cur-NPs may be a potential hepatoprotective agent for reducing liver oxidative stress caused by various stress factors.