Respiratory contamination is very common among ventilated infants. Therefore, judicious use of mechanical ventilation cannot be overemphasized. Gravitational force can ameliorate the onset of respiratory colonization. The mechanism and clinical applicability of such observations need to be explored further.

Intestinal lymphangiectasia (IL) is a rare disease characterized by dilatation of intestinal lymphatics. It can be classified as primary or secondary according to the underlying etiology. The clinical presentations of IL are pitting edema, chylous ascites, pleural effusion, acute appendicitis, diarrhea, lymphocytopenia, malabsorption, and intestinal obstruction. The diagnosis is made by intestinal endoscopy and biopsies. Dietary modification is the mainstay in the management of IL with a variable response. Here we report 2 patients with IL in Bahrain who showed positive response to dietary modification.

Background: Vitamin D deficiency is a global health problem in children. The vitamin D status of children and adolescents has not been evaluated in Bahrain. Aims: This cross-sectional study aimed to determine the prevalence of vitamin D deficiency in healthy children in Bahrain and to investigate the relationship between vitamin D level and age and sex. Methods: Medical records of children aged 1 month to 16 years who attended a vitamin D screening campaign at Al Kindi Specialized Hospital, Bahrain between September and October 2016 were reviewed. Data on sex and age were recorded and vitamin D level was measured as serum 25-hydroxyvitamin D [25(OH)D]. Children were grouped as: vitamin D sufficient [25(OH)D ≥ 75 nmol/L], vitamin D insufficient (51-74 nmol/L) and vitamin D deficient (≤ 50 nmol/L). Results: A total of 531 children were included in the study, 50.8% of whom were boys. Most of the children (93.4%) had low vitamin D levels; 78.3% were vitamin D deficient and 15.1% vitamin D insufficient. Only 6.6% were vitamin D sufficient. A significantly greater proportion of girls were vitamin D deficient than boys (P < 0.001). More primary-school children and adolescents were vitamin D deficient than preschool children (P < 0.001). A negative correlation was found between vitamin D level and age (r =-0.467; P < 0.001). Regression analysis showed that vitamin D level decreased by-2.164 nmol/L for each year of age. Conclusion: Vitamin D deficiency is a problem among healthy children in Bahrain. Public health policies or interventions are suggested to improve vitamin D status in Bahrain, especially for school-aged children.

PurposeThis study aimed to determine the prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among infants with neonatal indirect hyperbilirubinemia (NIH); compare G6PD-deficient and G6PD-normal patients regarding hyperbilirubinemia and need for exchange transfusions (ET); and assess risk factors for ET and kernicterus.MethodsThis is a case-control retrospective study. Medical records of NIH patients admitted to the Pediatric Department, Salmaniya Medical Complex, Bahrain, between January 2007 and June 2010 were reviewed. Data on sex, age at presentation, hospitalization duration, need for ET, hemoglobin (Hb) level, reticulocyte count, direct Coombs test, serum total and indirect bilirubin levels, thyroid function, blood and urine cultures, G6PD status, and blood groups were collected and compared between the G6PD-deficent and G6PD-normal patients.ResultsOf 1,159 NIH patients admitted, 1,129 were included, of whom 646 (57%) were male. Among 1,046 patients tested, 442 (42%) were G6PD deficient, 49 (4%) needed ET, and 11 (1%) had suspected Kernicterus. The G6PD-deficient patients were mainly male (P<0.0001), and had lower Hb levels (P<0.0001) and higher maximum bilirubin levels (P=0.001). More G6PD-deficient patients needed ET (P<0.0001). G6PD deficiency (P=0.006), lower Hb level (P=0.002), lower hematocrit count (P=0.02), higher bilirubin level (P<0.0001), higher maximal bilirubin level (P<0.0001), and positive blood culture result (P<0.0001) were significant risk factors for ET. Maximal bilirubin level was a significant risk factor for kernicterus (P=0.021) and independently related to ET (P=0.03).ConclusionG6PD deficiency is an important risk factor for severe NIH. In G6PD-deficent neonates, management of NIH should be hastened to avoid irreversible neurological complications.

No abstract