C-C cross-couplings constitute the largest diversity of organic reactions of chemical, biomedical, and industrial significance. They are also among the most frequently encountered reactions used in the synthesis of numerous drugs and relevant pharmaceutical substances. Development of an easily accessed, efficient, stable, and low cost catalyst is an attractive area of research in such kind of organic synthesis. This review highlights the remarkable and recent achievements made recently in the synthesis and use of palladium(II) complexes catalysts, that are based on heterocycles as ligands in their constitution, in the Suzuki-Miyaura cross-coupling.

Synthesis of a new phosphene-free nano-size formamidine-based palladium complex have been achieved. The molecular structure of novel palladium complex have been confirmed using spectroscopic methods of analysis as well as physical characterizations. The synthesized complex has been used as a catalyst for microwave assisted aqueous Suzuki-Miyaura Cross-coupling (SMC) of aryl bromides with phenylboronic acid. The formamidine-based Pd(II)-complex exhibited excellent catalytic activity to obtain biaryls using mild reaction conditions.

No abstract

No abstract

Thiazole derivatives 7b and 13a were superior to dabrafenib against B-RAFV600E kinase and potently inhibited the growth of WM266.4 melanoma cells. Compound 7b suppressed the phosphorylation of downstream ERK1/2 from WM266.4 cells.