Background: Studies conducted in public hospitals in Ghana have provided empirical evidence of an inadequate level of quality of health care services, both in terms of objective measures of client opinions and those of health care providers. Aim: The purpose of this study was to assess client satisfaction with the quality of healthcare delivery at the Child Health Department of the Tamale Teaching Hospital (TTH). Methods: A mixed-methods cross-sectional study design using purposeful and convenience sampling techniques were used to obtain 385 parents or caregivers and 6 health professionals at the Tamale Teaching Hospital (TTH) from July, 2021 to April, 2022. Structured questionnaires were used to collect quantitative data, and a semi-structured interview guide was used to collect qualitative data. Results: Most (90.9%) of the respondents are of the view that their children’s health needs were catered for in the facility while only 0.2% of respondents strongly disagreed that their child’s health needs were catered for in the facility. The study indicates that the 1st most ranked important satisfactory factor to the client’s healthcare service quality is tangibility with an RII of 1.20 and the least ranked was priority and responsiveness of RII of 0.40 respectively. Conclusions: Child healthcare service patronage in TTH is generally high. Although the needs of the people are met, we recommend that the management of the hospital should prioritize medical and surgical conditions in the hospital by providing equipment and logistics.