Background: Preeclampsia (PE) is a hypertensive disorder of pregnancy associated with significant maternal morbidity and mortality. The outcome of the disease depends to a large extent on risk factors, maternal vascular responsiveness, screening performance and prevention effectiveness. Fetal medicine foundation has developed an online calculator that predicts the risk for PE in pregnant woman in first trimester using MUAPI (mean uterine artery pulsatility index) and maternal factors.Methods: Diagnostic test evaluation of FMF (fetal medicine foundation) calculator done using data collected from consenting 316 women with singleton pregnancy between the gestational age 11 weeks to 14 weeks+1 day who fulfilled inclusion and exclusion criteria. All cases were followed up and results were analyzed statistically.Results: FMF calculator predicted a high-risk population of 12 pregnant women. On follow up of 316 subjects 13 pregnant women developed preterm preeclampsia with an incidence of 4.1%. Among high-risk population 9 subjects developed preterm PE and among the 304 cases in low-risk group 4 patient developed preterm PE. In this study sensitivity of FMF calculator was 69.2% and specificity was 99% with a PPV of 75, NPV of 98.6, positive likelihood ratio of 69.9 and diagnostic odds ratio of 225. The area under ROC was 0.841 with 95% CI (0.711-0.972) was high indicating that the algorithm was able to differentiate between pregnant women at high or low risk for preterm PE.Conclusions: This study concludes that the algorithm used in FMF calculator in first trimester is highly specific and have high sensitivity for predicting preterm PE and can be used in routine clinical practice to identify women at high risk.

Background: Due to the global burden of obesity and type 2 diabetes, prevalence of NAFLD is now increasing, becoming one of the most common cause of chronic liver disease and liver transplantation both for end-stage liver disease and hepatocellular carcinoma. Although traditionally liver biopsy is gold standard for diagnosis of NAFLD, majority of patients can be non-invasively diagnosed with various tools like scoring systems (NAFLD fibrosis score, BARD score), ultrasound and MR elastographic techniques. The primary objective of this study was to assess the liver stiffness measurement by shear wave elastography and assess correlation between LSM by SWE and NAFLD fibrosis score in NAFLD patients.Methods: This is a descriptive study comprising 75 patients with clinical suspicion of NAFLD, referred from Gastroenterology department from January 2020 to June 2021. All patients had undergone SWE, NAFLD fibrosis score calculated and results analyzed.Results: Among the 75 patients studied, applying low cut off value of NAFLD fibrosis score (below -1.455), the presence of advanced fibrosis was excluded and by applying the high cut off point (>0.676) majority of subjects had advanced fibrosis. The NAFLD fibrosis score was correlated with E median values of liver stiffness measurement using Pearson correlation test and showed a moderate positive correlation (p=0.0001, =0.685) between both the variables.Conclusions: Our study showed positive moderate correlation between NAFLD fibrosis score and LSM by 2D SWE. Multistep strategies using liver 2D SWE and NAFLD fibrosis score in combination can be used in the future to accurately diagnose or exclude the presence of advanced fibrosis in NAFLD patients.