Background and Aim: Infertility is one year of regular sexual intercourse without a successful pregnancy. The first and most common form of ART is In-vitro fertilization (IVF). In animal studies, royal jelly is the treatment supplementary to improve fertility. Therefore, this study aims to evaluate the effect of royal jelly on the quality of the ovum and fetus in unsubstantiated women under treatment. Methods: The study was a randomized clinical trial on women under 40 years old. 110 infertile women with low ovarian reserve were included in the study. After measuring FSH, LH, TSH, prolactin, anti-mullerian hormone, fasting insulin, and estradiol on the third day of menstruation were divided into two groups: intervention and control groups. The Royal Gel Intervention Group received one gram daily for two months before the IVF Intracytoplasmic Sperm Injection cycle, and the control group received a placebo, similar to the intervention capsule. The quantitative and qualitative amounts of eggs and fetuses were evaluated, and eventually, the clinical pregnancy due to fetal transmission was measured after determining the ratio of immature and atretic ovum to adult ovum in the experimental groups and the fertilization of the fetus. The embryos are qualitatively graded. The results were analyzed and compared by IBM SPSS Statistics 26.0.0.1 software. Results: The average age was 30.3 ± 5.7 years. The two groups were not significantly different in age, BMI, AMH (anti-mullerian hormone), FSH, LH, TSH, Prolactin, and estradiol, but were significantly different in the result received from the level of fasting insulin. The consequences for the fetus and the oocytes are not significantly different in the two groups of control. The IVF result was significantly related to the study group, with the percentage of IVF-positive cases in the case group being 66.7% and in the control group at 30%. Conclusion: IVF successful outcome is significantly higher in the candidates using Royal Jelly capsule.

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