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Despite the existence of modern antidiabetic medications, diabetes still affects millions of individuals worldwide, with a high death and disability rate. There has been a concerted search for alternative natural medicinal agents; luteolin (LUT), a polyphenolic molecule, might be a good choice, both because of its efficacy and because of it having fewer side effects, compared to conventional medicines. This study aims to explore the antidiabetic potential of LUT in diabetic rats, induced by streptozotocin (STZ; 50 mg/kg b.w.), intraperitoneally. The level of blood glucose, oral glucose tolerance test (OGTT), body weight, glycated hemoglobin A1c (HbA1c), lipidemic status, antioxidant enzymes, and cytokines were assessed. Also, its action mechanism was explored through molecular docking and molecular dynamics simulations. Oral supplementation of LUT for 21 days resulted in a significant decrease in the blood glucose, oxidative stress, and proinflammatory cytokine levels, and modulated the hyperlipidemia profile. LUT also ameliorated the tested biomarkers of liver and kidney function. In addition, LUT markedly reversed the damage to the pancreas, liver, and kidney cells. Moreover, molecular docking and molecular dynamics simulations revealed excellent antidiabetic behavior of LUT. In conclusion, the current investigation revealed that LUT possesses antidiabetic activity, through the reversing of hyperlipidemia, oxidative stress, and proinflammatory status in diabetic groups. Therefore, LUT might be a good remedy for the management or treatment of diabetes.

Abstract-In this paper we are using intuitionistic fuzzy approach to minimize search domain in an accidental case where the data collected for investigation is intuitionistic fuzzy in nature. To handle these types of imprecise information we use intuitionistic fuzzy tolerance relation and translate intuitionistic fuzzy query to reach to the conclusion. Here we present an example of vehicle hit and run case where the accused had fled the accident spot within seconds leaving no clue behind.

Intel SGX has been a popular trusted execution environment (TEE) for protecting the integrity and confidentiality of applications running on untrusted platforms such as cloud. However, the access patterns of SGX-based programs can still be observed by adversaries, which may leak important information for successful attacks. Researchers have been experimenting with Oblivious RAM (ORAM) to address the privacy of access patterns. ORAM is a powerful low-level primitive that provides application-agnostic protection for any I/O operations, however, at a high cost. We find that some application-specific access patterns, such as sequential block I/O, do not provide additional information to adversaries. Others, such as sorting, can be replaced with specific oblivious algorithms that are more efficient than ORAM. The challenge is that developers may need to look into all the details of application-specific access patterns to design suitable solutions, which is time-consuming and error-prone. In this paper, we present the lightweight SGX based MapReduce (SGX-MR) approach that regulates the dataflow of data-intensive SGX applications for easier application-level access-pattern analysis and protection. It uses the MapReduce framework to cover a large class of data-intensive applications, and the entire framework can be implemented with a small memory footprint. With this framework, we have examined the stages of data processing, identified the access patterns that need protection, and designed corresponding efficient protection methods. Our experiments show that SGX-MR based applications are much more efficient than the ORAM-based implementations.