Introduction:The role of surgical treatment for chronic functional constipation in children remains unclear. The objective of this study was to analyze clinical cases of patients qualified for surgical treatment. Material and methods: We analized data of 160 pediatric patients hospitalized in 2013-2021. Thirteen patients subjected to surgical treatment. Results:The study group consisted of 13 children. Organic causes of constipation were excluded. The duration of problems before qualification for surgical treatment averaged at 5.7 ±2.7 years. The most common symptoms were psychological disorders (13/13), abdominal pain (12/13) and fecal overflow incontinence (12/13). All patients were qualified for stepwise treatment: colostomy formation, segmental resection, and stoma closure. All children experienced subjective functional improvement. No severe surgical complications were observed. Conclusions: In cases of functional constipation refractory to conservative treatment,, surgical treatment facilitates immediate improvement in symptoms and social functioning. Any surgical treatment should be preceded by the exclusion of organic causes of constipation.

Background: The identification of parameters that would serve as predictors of prognosis in COVID-19 patients is very important. In this study, we assessed independent factors of in-hospital mortality of COVID-19 patients during the second wave of the pandemic. Material and methods: The study group consisted of patients admitted to two hospitals and diagnosed with COVID-19 between October 2020 and May 2021. Clinical and demographic features, the presence of comorbidities, laboratory parameters, and radiological findings at admission were recorded. The relationship of these parameters with in-hospital mortality was evaluated. Results: A total of 1040 COVID-19 patients (553 men and 487 women) qualified for the study. The in-hospital mortality rate was 26% across all patients. In multiple logistic regression analysis, age ≥ 70 years with OR = 7.8 (95% CI 3.17–19.32), p < 0.001, saturation at admission without oxygen ≤ 87% with OR = 3.6 (95% CI 1.49–8.64), p = 0.004, the presence of typical COVID-19-related lung abnormalities visualized in chest computed tomography ≥40% with OR = 2.5 (95% CI 1.05–6.23), p = 0.037, and a concomitant diagnosis of coronary artery disease with OR = 3.5 (95% CI 1.38–9.10), p = 0.009 were evaluated as independent risk factors for in-hospital mortality. Conclusion: The relationship between clinical and laboratory markers, as well as the advancement of lung involvement by typical COVID-19-related abnormalities in computed tomography of the chest, and mortality is very important for the prognosis of these patients and the determination of treatment strategies during the COVID-19 pandemic.

Introduction: COVID-19 is a prominently respiratory infection, with potential renal complications. Our objective was to describe the incidence of renal impairment and its influence on clinical outcome in patients admitted to University Hospital No 1 in Bydgoszcz due to COVID-19.Material and methods: In this single-center observational study we retrospectively identified patients with a positive test result for SARS-CoV-2 from either a nasopharyngeal or oropharyngeal swab PCR (n = 988) who were admitted to University Hospital No 1 in Bydgoszcz, Poland since April 1, 2020 to April 30, 2021. Details of the patients' demographics, diagnoses (based on ICD-10 codes), eGFR and clinical outcomes were obtained using a combination of a manual chart review of the electronic medical record from the hospital database.Results: Median baseline eGFR was 77,4 ml/min (IQR 51,6-93,7 ml/min) and minimal eGFR was 68,7 ml/min (IQR 39,9-90 ml/min), p < 0,05. We found significant differences in median baseline and minimal eGFR between patients discharged and deceased (80,8 vs. 55,4 ml/min and 73,7 vs. 33 ml/min, respectively, p < 0,001). Patients who died (12,5 %) were older, with more co-morbidities including CKD and AKI, and presented a significantly lower value of eGFR both at baseline and during hospital stay, as well as, more frequent and extensive deterioration of eGFR. Factors predisposing to in-hospital death were age, atrial fibrillation, heart failure, coronary artery disease, and among them AKI and CKD were strong negative prognostic parameters.Conclusions: Renal impairment on admission as well as during hospitalization among patients with SARS-CoV-2 infection is a risk factor of negative outcome.