Canker sore which in medical terms is called aphthous stomatitis is a wound in the mouth that can cause pain and discomfort. Piper betel leaf can be used for strengthening the teeth, cure canker sores, treat the bad breath and stop the gum from bleeding. The research aimed to determine the edible film formula of betel leaf ethanol extract that met the physical evaluation requirements and to determine the effect of variation concentration of sorbitol and HPMC (Hydroxypropyl methylcellulose) on the physical evaluation. Edible film preparation from betel leaf extract is a thin layer made from the basic ingredients of corn starch, sorbitol, and HPMC. In this research, 3 edible film formulas were made with variations in the concentration of sorbitol and HPMC, namely: F1 (5%;5%), F2 (4%;4%), F3 (3%;3%). Data of evaluation results were analyzed statistics by Kruskal wallis method. The results showed that F1, F2 and F3 meet the physical evaluation requirements for edible film dosage. Variations in the concentration of sorbitol and HPMC gave different results significantly influence (p<0.05) on weight uniformity, film thickness, solubility and dissolution time, and did not significantly influence (p>0.05) on the organoleptic test, fragility of edible film, water resistance (swelling) and moisture content.Keywords: Betel leaf extract, edible film, HPMC, canker sore, sorbitol