Objectives Assessment of the impact of pooling five single‐donor plasma (SDP) units to obtain six pathogen‐reduced therapeutic plasma (PTP) units on standardisation and the retention of labile coagulation factors. Background SDP shows a high inter‐donor variability with potential implications for the clinical treatment outcome. Additionally, there is still an existing risk for window‐period transmissions of blood borne pathogens including newly emerging pathogens. Methods/Materials Five ABO‐identical SDP units were pooled, treated with the INTERTCEPT™ Blood System (Cerus Corporation, U.S.A.) and split into six PTP units which were frozen and thawed after 30 days. The variability in volume, labile coagulation factor retention and activity was assessed. Results The variability of volumes between the PTP units was reduced by 46% compared to SDP units. The variability in coagulation factor content between the PTP units was reduced by 63% compared to SDP units. Moderate, but significant losses of coagulation factors (except for vWF) were observed in PTPs compared to SDPs. Conclusion The pooling of five SDP units to obtain six PTP units significantly increases product standardisation with potential implications for safety, economics as well as transfusion‐transmitted pathogen safety, making it an interesting alternative to quarantine SDP (qSDP) and pathogen‐reduced SDP.

Introduction. One of the key elements of blood safety is automated whole blood processing. The Regional Blood Transfusion Center (BC) in Łódź had the Reveos system installed in 2017. By combining centrifugation and fractionation press, the Reveos system provides full automation of whole blood processing so it minimizes the risk of human error and ensures more accuracy and repeatability. The study aim is was determine and compare the quality control parameters of blood components obtained with Compomat G5, Optipress II and the Reveos system as well as to compare the level of compliance with current quality requirements and recommendations. Materials and methods. 150 units of whole blood were processed into blood components using the 3 above mentioned systems. Selected parameters were determined. Results. The following parameters were determined for blood components obtained with